High-Throughput Identification of Epigenetic Compounds to Enhance Chicken Host Defense Peptide Gene Expression
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DOI: 10.3390/antibiotics11070933
Abstract: Enhancing the synthesis of endogenous host defense peptides (HDPs) has emerged as a novel antibiotic-free approach to infectious disease control and prevention. A number of epigenetic compounds have been identified as HDP inducers and several… read more here.
Keywords: high throughput; gene expression; host defense; gene ... See more keywords
High-Throughput Screening for Epigenetic Compounds That Induce Human β-Defensin 1 Synthesis
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DOI: 10.3390/antibiotics12020186
Abstract: Antimicrobial host defense peptides (HDPs) are critically important for innate immunity. Small-molecule compounds with the ability to induce HDP synthesis are being actively explored for antimicrobial therapy. To facilitate the discovery of the compounds that… read more here.
Keywords: throughput screening; synthesis; high throughput; human defensin ... See more keywords
Functional Drug Screening of Small Molecule Inhibitors of Epigenetic Modifiers in Refractory AML Patients
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DOI: 10.3390/cancers14174094
Abstract: Simple Summary Acute myeloid leukemia is a cancer originating in the bone marrow and peripheral blood. Genetic mutations observed with the disease are difficult to target therapeutically and patients often have different treatment responses to… read more here.
Keywords: aml patients; disease; inhibitors epigenetic; epigenetic modifiers ... See more keywords