Evidence for Noncytosine Epigenetic DNA Modifications in Multicellular Eukaryotes: An Overview.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0876-0_2
Abstract: Cytosine DNA methylation (5-methylcytsone, 5mC) is the major DNA modification found in the genomes of animals and plants. Although the roles of 5mC and its oxidized derivatives in the regulation of gene expression are relatively… read more here.
Keywords: epigenetic dna; dna; evidence noncytosine; noncytosine epigenetic ... See more keywords
Hyperactive DNA Cutting for Unbiased UHPLC-MS/MS Quantification of Epigenetic DNA Marks by Engineering DNase I Mutants.
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DOI: 10.1021/acs.analchem.2c04485
Abstract: Epigenetic DNA modifications, such as 5-methylcytosine, 5-hydroxymethylcytosine, and 5-formylcytosine, are associated with a variety of diseases and potential biomarkers for cancer diagnosis and therapy. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays are considered to be the… read more here.
Keywords: quantification; dna; dna cutting; dnase mutants ... See more keywords
Urinary Measurement of Epigenetic DNA Modifications and 8-oxodG as Possible Noninvasive Markers of Colon Cancer Evolution
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DOI: 10.3390/ijms232213826
Abstract: The active DNA demethylation mechanism involves 5-methylcytosine (5-mCyt) enzymatic oxidation with the subsequent formation of 5-hydroxymethylcytosine (5-hmCyt), which can be further oxidized to 5-formylcytosine (5-fCyt) and 5-carboxylcytosine (5-caCyt). The products of active DNA demethylation are… read more here.
Keywords: measurement epigenetic; dna; urinary measurement; crc ... See more keywords