Epigenetic downregulation of TET3 reduces genome‐wide 5hmC levels and promotes glioblastoma tumorigenesis
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DOI: 10.1002/ijc.32520
Abstract: Loss of 5‐hydroxymethylcytosine (5hmC) has been associated with mutations of the ten–eleven translocation (TET) enzymes in several types of cancer. However, tumors with wild‐type TET genes can also display low 5hmC levels, suggesting that other… read more here.
Keywords: genome wide; 5hmc levels; epigenetic downregulation; glioblastoma tumorigenesis ... See more keywords
NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin
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DOI: 10.1177/17448069231158289
Abstract: Neuropathic pain is a common dose-limiting side effect of oxaliplatin, which hampers the effective treatment of tumors. Here, we found that upregulation of transcription factor NFATc2 decreased the expression of Beclin-1, a critical molecule in… read more here.
Keywords: epigenetic downregulation; neuropathic pain; beclin; pain ... See more keywords