Aging: Somatic Mutations, Epigenetic Drift and Gene Dosage Imbalance.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2016.11.006
Abstract: Aging involves a progressive decline of metabolic function and an increased incidence of late-onset degenerative disorders and cancer. To a large extent, these processes are influenced by alterations affecting the integrity of genome architecture and,… read more here.
Keywords: mutations epigenetic; gene dosage; somatic mutations; aging somatic ... See more keywords
Epigenetic Drift Is a Determinant of Mammalian Lifespan.
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DOI: 10.1089/rej.2017.2024
Abstract: The epigenome, which controls cell identity and function, is not maintained with 100% fidelity in somatic animal cells. Errors in the maintenance of the epigenome lead to epigenetic drift, an important hallmark of aging. Numerous… read more here.
Keywords: dna methylation; drift; epigenetic drift; lifespan ... See more keywords
Identification of a key role of widespread epigenetic drift in Barrett’s esophagus and esophageal adenocarcinoma
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DOI: 10.1186/s13148-017-0409-4
Abstract: BackgroundRecent studies have identified age-related changes in DNA methylation patterns in normal and cancer tissues in a process that is called epigenetic drift. However, the evolving patterns, functional consequences, and dynamics of epigenetic drift during… read more here.
Keywords: drift; methylation; barrett esophagus; esophagus esophageal ... See more keywords