Targeting Autophagy-Related Epigenetic Regulators for Cancer Drug Discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00579
Abstract: Existing evidence has demonstrated that epigenetic modifications (including DNA methylation, histone modifications, and microRNAs), which are associated with the occurrence and development of tumors, can directly or indirectly regulate autophagy. In particular, nuclear events induced… read more here.
Keywords: epigenetic regulators; targeting autophagy; epigenetic drugs; autophagic process ... See more keywords
Epigenetic drugs
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DOI: 10.1038/s41587-020-0523-2
Abstract: Recent patents for pharmaceutical compounds comprising and treatments using histone deacetylase and DNA methyltransferase inhibitors. read more here.
Keywords: epigenetic drugs;
ATF3 Coordinates Antitumor Synergy between Epigenetic Drugs and Protein Disulfide Isomerase Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-4046
Abstract: This study uses a first-in-class PDI inhibitor entering clinical development to enhance the effects of epigenetic drugs in some of the deadliest forms of cancer. Histone deacetylase inhibitors (HDACi) are largely ineffective in the treatment… read more here.
Keywords: protein disulfide; epigenetic drugs; cancer; pdi ... See more keywords
Abstract 4488: Immunomodulatory activity of epigenetic drugs: Laying the ground for new combined immunotherapeutic strategies for glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-4488
Abstract: Rationale: Glioblastoma multiforme (GBM) is the most common and deadliest primary brain tumour in adults, with a very dismal prognosis and limited effective therapies. Immunotherapy may play a role in treating GBM, though the initial… read more here.
Keywords: guadecitabine; mage; gbm; epigenetic drugs ... See more keywords
Epigenetic Drugs in the Treatment of Endometriosis
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DOI: 10.1177/1933719118765987
Abstract: We read with great interest the study by Seo et al1 entitled “Trichostatin A induces NAG-1 expression and apoptosis in human endometriotic stromal cells” published in your journal. The authors investigated the use of trichostatin… read more here.
Keywords: endometriosis; treatment endometriosis; apoptosis; epigenetic drugs ... See more keywords
Epigenetic Drugs and Their Immune Modulating Potential in Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020211
Abstract: Epigenetic drugs are used for the clinical treatment of hematologic malignancies; however, their therapeutic potential in solid tumors is still under investigation. Current evidence suggests that epigenetic drugs may lead to antitumor immunity by increasing… read more here.
Keywords: immune modulating; drugs immune; epigenetic drugs; potential cancers ... See more keywords
PPARα in the Epigenetic Driver Seat of NAFLD: New Therapeutic Opportunities for Epigenetic Drugs?
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10123041
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic and the most common cause of chronic liver disease worldwide. It consists of a spectrum of liver disorders ranging from simple steatosis to NASH which predisposes… read more here.
Keywords: new therapeutic; ppar; epigenetic drugs; driver seat ... See more keywords
Epigenetic drugs in somatostatin type 2 receptor radionuclide theranostics and radiation transcriptomics in mouse pheochromocytoma models
Sign Up to like & getrecommendations! Published in 2023 at "Theranostics"
DOI: 10.7150/thno.77918
Abstract: Pheochromocytomas and paragangliomas (PCCs/PGLs) are catecholamine-producing tumors. In inoperable and metastatic cases, somatostatin type 2 receptor (SSTR2) expression allows for peptide receptor radionuclide therapy with [177Lu]Lu-DOTA-TATE. Insufficient receptor levels, however, limit treatment efficacy. This study… read more here.
Keywords: receptor radionuclide; somatostatin type; epigenetic drugs; sstr2 ... See more keywords