Mechanistic aspects of epigenetic dysregulation in SLE.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical immunology"
DOI: 10.1016/j.clim.2018.02.002
Abstract: Epigenetic events have been linked with disease expression in individuals genetically predisposed to the development of systemic lupus erythematosus (SLE), a severe systemic autoimmune/inflammatory disease. Altered DNA methylation and hydroxymethylation as well as histone modifications… read more here.
Keywords: aspects epigenetic; sle; dysregulation sle; mechanistic aspects ... See more keywords
Extended transcriptome analysis reveals genome-wide lncRNA-mediated epigenetic dysregulation in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2020.11.004
Abstract: It is estimated that the rate of epigenetic changes may be orders of magnitude higher than that of genetic changes and that purely epigenetic mechanisms may explain why cancers arise with few or no recurrent… read more here.
Keywords: genome wide; analysis; dysregulation; colorectal cancer ... See more keywords
Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.07.006
Abstract: The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms of cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to… read more here.
Keywords: cml; epigenetic mechanisms; dysregulation chronic; chronic myeloid ... See more keywords
Epigenetic dysregulation in myeloid malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2019004262
Abstract: Epigenetic deregulation is now a well-recognized -though not yet fully understood- mechanism that contributes to the development and progression of myeloid malignancies. In the past 15 years, next generation sequencing studies have revealed patterns of… read more here.
Keywords: myeloid malignancies; epigenetic dysregulation; myeloid; dysregulation myeloid ... See more keywords
Maternal Epigenetic Dysregulation as a Possible Risk Factor for Neurodevelopmental Disorders
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14030585
Abstract: Neurodevelopmental Disorders (NDs) are a heterogeneous group of disorders and are considered multifactorial diseases with both genetic and environmental components. Epigenetic dysregulation driven by adverse environmental factors has recently been documented in neurodevelopmental disorders as… read more here.
Keywords: dysregulation possible; neurodevelopmental disorders; possible risk; maternal epigenetic ... See more keywords