Abstract NG04: Somatic mutations drive specific but reversible epigenetic heterogeneity states in AML
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-ng04
Abstract: Cells from the same tumor can exhibit significant variation in their genomes, epigenomes, and transcriptomes, resulting in distinct cellular phenotypes. Such intra-tumor heterogeneity is a substrate for tumor evolution, e.g. generating cell clones with a… read more here.
Keywords: epigenetic clonality; heterogeneity; somatic mutations; reversible epigenetic ... See more keywords
Abstract LB131: Association between epigenetic heterogeneity of esophageal adenocarcinoma and response to first-line immunochemotherapy in LUD2015-005 Trial
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb131
Abstract: Immune checkpoint inhibitors (ICI) were recently approved as a first-line treatment for inoperable esophageal adenocarcinomas (EAC) in combination with chemotherapy (CTX). Unfortunately, even though EAC has one of the highest tumor mutation burdens among all… read more here.
Keywords: methylation; response; first line; epigenetic heterogeneity ... See more keywords
COCOA: coordinate covariation analysis of epigenetic heterogeneity
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DOI: 10.1186/s13059-020-02139-4
Abstract: A key challenge in epigenetics is to determine the biological significance of epigenetic variation among individuals. We present Coordinate Covariation Analysis (COCOA), a computational framework that uses covariation of epigenetic signals across individuals and a… read more here.
Keywords: covariation analysis; covariation; coordinate covariation; epigenetic heterogeneity ... See more keywords
Distinct promoter methylation profile reveals spatial epigenetic heterogeneity in 2 myeloma patients with multifocal extramedullary relapses
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DOI: 10.1186/s13148-018-0597-6
Abstract: Spatial and subclonal genetic heterogeneity in multiple myeloma (MM) have been demonstrated by sequencing of plasma cells from multi-focal regions, but studies of spatial epigenetic heterogeneity are scanty. Herein, promoter methylation status of genes implicated… read more here.
Keywords: methylation; heterogeneity; promoter methylation; epigenetic heterogeneity ... See more keywords
Epigenetic heterogeneity in cancer
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DOI: 10.1186/s40364-019-0174-y
Abstract: Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor genotype variations among tumors within different patients are known as interpatient heterogeneity, and variability among multiple tumors of the same type arising… read more here.
Keywords: heterogeneity cancer; heterogeneity; epigenetic heterogeneity; cancer ... See more keywords