Epigenetic histone modulations of PPARγ and related pathways contribute to olanzapine-induced metabolic disorders.
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DOI: 10.1016/j.phrs.2020.104703
Abstract: The antipsychotic drug olanzapine is widely used in the treatment of schizophrenia, bipolar and other mental disorders; however, it causes serious metabolic disorders, including dyslipidemia. Our previous studies have identified that olanzapine activated expression of… read more here.
Keywords: olanzapine induced; epigenetic histone; metabolic disorders; histone ... See more keywords
Dextromethorphan Suppresses Lipopolysaccharide-Induced Epigenetic Histone Regulation in the Tumor Necrosis Factor-α Expression in Primary Rat Microglia
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DOI: 10.1155/2020/9694012
Abstract: The activation of microglial cells plays an important role in the cascade of events leading to inflammation-mediated neurodegenerative disorders. Precision therapeutics require that adjunctively feasible drugs be found to prevent microglial cell activation and prevent… read more here.
Keywords: epigenetic histone; expression; tumor necrosis; microglial cells ... See more keywords