Inheritance and maintenance of small RNA‐mediated epigenetic effects
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DOI: 10.1002/bies.202100284
Abstract: Heritable traits are predominantly encoded within genomic DNA, but it is now appreciated that epigenetic information is also inherited through DNA methylation, histone modifications, and small RNAs. Several examples of transgenerational epigenetic inheritance of traits… read more here.
Keywords: information; maintenance small; epigenetic information; inheritance maintenance ... See more keywords
Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans.
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DOI: 10.1016/j.celrep.2020.02.050
Abstract: Changes in epigenetic states affect organismal homeostasis, including stress resistance. However, the mechanisms coordinating epigenetic states and systemic stress resistance remain largely unknown. Here, we identify the intestine-to-germline communication of epigenetic states, which intergenerationally enhances… read more here.
Keywords: systemic stress; intestine germline; stress resistance; resistance ... See more keywords
Early life lessons: The lasting effects of germline epigenetic information on organismal development
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.12.004
Abstract: Background An organism's metabolic phenotype is primarily affected by its genotype, its lifestyle, and the nutritional composition of its food supply. In addition, it is now clear from studies in many different species that ancestral… read more here.
Keywords: information; lessons lasting; early life; life lessons ... See more keywords
Strategies for the acquisition of transcriptional and epigenetic information in single cells.
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DOI: 10.21037/jtd.2016.08.17
Abstract: As the basic unit of living organisms, each single cell has unique molecular signatures and functions. Our ability to uncover the transcriptional and epigenetic signature of single cells has been hampered by the lack of… read more here.
Keywords: single cell; transcriptional epigenetic; single cells; epigenetic information ... See more keywords
Loss of epigenetic information as a cause of mammalian aging
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DOI: 10.2139/ssrn.3951490
Abstract: All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization of chromatin-modifying proteins to DNA breaks,… read more here.
Keywords: information; epigenetic information; loss epigenetic; information cause ... See more keywords
Paternal Contributions to Offspring Health: Role of Sperm Small RNAs in Intergenerational Transmission of Epigenetic Information
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00215
Abstract: The most fundamental process for the perpetuation of a species is the transfer of information from parent to offspring. Although genomic DNA contributes to the majority of the inheritance, it is now clear that epigenetic… read more here.
Keywords: information; inheritance; sperm small; small rnas ... See more keywords