SA17 PATERNAL AGE AFFECTS OFFSPRING'S BEHAVIOR POSSIBLY VIA EPIGENETIC MECHANISM RECRUITING A TRANSCRIPTIONAL REPRESSOR REST
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.089
Abstract: Background Paternal age has deleterious effects on the transmission of phenotypes to offspring, including higher prevalence of major psychiatric and neurodevelopmental disorders. Methods Here, we examined transgenerational transmission of selected somatic and cognitive phenotypes in… read more here.
Keywords: rest; repressor; epigenetic mechanism; paternal age ... See more keywords
Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies
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DOI: 10.2147/ott.s192234
Abstract: Ubiquitin-like with plant homeodomain and really interesting new gene finger domains 1 (UHRF1) functions as an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat-interactive protein by multiple… read more here.
Keywords: mechanism target; uhrf1 protein; target therapy; protein ... See more keywords
Epigenetic Mechanism and Therapeutic Implications of Atrial Fibrillation
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DOI: 10.3389/fcvm.2021.763824
Abstract: Atrial fibrillation (AF) is the most common arrhythmia attacking 1. 5–2.0% of general population worldwide. It has a significant impact on morbidity and mortality globally and its prevalence increases exponentially with age. Therapies like catheter… read more here.
Keywords: fibrillation; mechanism therapeutic; therapeutic implications; atrial fibrillation ... See more keywords