Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.02.010
Abstract: Stem cells determine homeostasis and repair of many tissues and are increasingly recognized as functionally heterogeneous. To define the extent of—and molecular basis for—heterogeneity, we overlaid functional, transcriptional, and epigenetic attributes of hematopoietic stem cells… read more here.
Keywords: epigenetic memory; cell; hematopoietic stem; stem ... See more keywords
Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06236-8
Abstract: Paternal contributions to epigenetic inheritance are not well understood. Paternal contributions via marked nucleosomes are particularly understudied, in part because sperm in some organisms replace the majority of nucleosome packaging with protamine packaging. Here we… read more here.
Keywords: based epigenetic; epigenetic memory; histone based; caenorhabditis elegans ... See more keywords
Identification of epigenetic memory candidates associated with gestational age at birth through analysis of methylome and transcriptional data
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83016-3
Abstract: Preterm birth is known to be associated with chronic disease risk in adulthood whereby epigenetic memory may play a mechanistic role in disease susceptibility. Gestational age (GA) is the most important prognostic factor for preterm… read more here.
Keywords: epigenetic memory; transcriptional data; analysis methylome; birth ... See more keywords
Human Induced Pluripotent Stem Cells: From Cell Origin, Genomic Stability, and Epigenetic Memory to Translational Medicine
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells"
DOI: 10.1093/stmcls/sxac020
Abstract: Abstract The potential of human induced pluripotent stem cells (iPSCs) to self-renew indefinitely and to differentiate virtually into any cell type in unlimited quantities makes them attractive for in vitro disease modeling, drug screening, personalized… read more here.
Keywords: stem cells; medicine; epigenetic memory; human induced ... See more keywords
Oncogenic lncRNAs alter epigenetic memory at a fragile chromosomal site in human cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl5621
Abstract: Chromosome instability is a critical event in cancer progression. Histone H3 variant CENP-A plays a fundamental role in defining centromere identity, structure, and function but is innately overexpressed in several types of solid cancers. In… read more here.
Keywords: epigenetic memory; oncogenic lncrnas; memory fragile; human cancer ... See more keywords
Modulating epigenetic memory through vitamins and TET: implications for regenerative medicine and cancer treatment.
Sign Up to like & getrecommendations! Published in 2017 at "Epigenomics"
DOI: 10.2217/epi-2017-0021
Abstract: Vitamins A and C represent unrelated sets of small molecules that are essential to the human diet and have recently been shown to intensify erasure of epigenetic memory in naive embryonic stem cells. These effects… read more here.
Keywords: medicine; epigenetic memory; treatment; cancer ... See more keywords
Epigenetic Memory: Lessons From iPS Cells Derived From Human β Cells
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.614234
Abstract: Incomplete reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) may be responsible for the heterogeneity in differentiation capacity observed among iPSC lines. It remains unclear whether it results from stochastic reprogramming events, or… read more here.
Keywords: epigenetic memory; memory lessons; differentiation; cell ... See more keywords