Molecular regulation of hypoxia through the lenses of noncoding RNAs and epitranscriptome
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1750
Abstract: Cells maintain homeostasis in response to environmental stress through specific cell stress responses. Hypoxic stress, well known to be associated with diverse solid tumors, is one of the main reasons for cancer‐related mortality. Although cells… read more here.
Keywords: regulation hypoxia; rnas epigenetic; epigenetic modifiers; noncoding rnas ... See more keywords
Macrophage polarization in response to epigenetic modifiers during infection and inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2016.08.006
Abstract: Macrophages are a heterogeneous population of phagocytic cells present in all tissues. Recently, several drugs that target the epigenetic machinery have emerged as attractive molecules for treating infection and inflammation by modulating macrophages. Treatment of… read more here.
Keywords: polarization response; macrophage polarization; infection inflammation; response epigenetic ... See more keywords
Epigenetic regulation of radioresistance: insights from preclinical and clinical studies
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2158810
Abstract: ABSTRACT Introduction Oftentimes, radiation therapy (RT) is ineffective due to the development of radioresistance (RR). However, studies have shown that targeting epigenetic modifiers to enhance radiosensitivity represents a promising direction of clinical investigation. Areas covered… read more here.
Keywords: targeting epigenetic; preclinical clinical; clinical studies; epigenetic modifiers ... See more keywords
Epigenetic modifiers as game changers for healthy ageing.
Sign Up to like & getrecommendations! Published in 2023 at "Rejuvenation research"
DOI: 10.1089/rej.2022.0059
Abstract: Epigenetic alterations during ageing are manifested with altered gene expression linking it to lifespan regulation, genetic instability, and diseases. Diet and epigenetic modifiers exert a profound effect on the lifespan of an organism by modulating… read more here.
Keywords: healthy ageing; epigenetic modifiers; changers healthy; game changers ... See more keywords
DIPG-12. TARGETING EPIGENETIC MODIFIERS TO INDUCE IMMUNE SIGNALING IN DIPG
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.062
Abstract: Abstract DIPG is a universally fatal pediatric brainstem tumor with no effective therapy. Recent work has shown that over 80% of DIPG cases harbor the H3K27M mutation leading to global loss of the repressive H3K27… read more here.
Keywords: dipg targeting; targeting epigenetic; modifiers induce; induce immune ... See more keywords
Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant-associated ALCL.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019001904
Abstract: The oncogenic events involved in breast implant-associated anaplastic large cell lymphoma (BI-ALCL) remain elusive. To clarify this point, we have characterized the genomic landscape of 34 BI-ALCLs (15 tumor, 19 in situ subtypes) collected from… read more here.
Keywords: breast implant; alterations epigenetic; jak stat; implant associated ... See more keywords
MicroRNA Regulation of Epigenetic Modifiers in Breast Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11070897
Abstract: Epigenetics refers to the heritable changes in gene expression without a change in the DNA sequence itself. Two of these major changes include aberrant DNA methylation as well as changes to histone modification patterns. Alterations… read more here.
Keywords: regulation epigenetic; breast cancer; microrna regulation; cancer ... See more keywords
Epigenetic Modifiers as Novel Therapeutic Targets and a Systematic Review of Clinical Studies Investigating Epigenetic Inhibitors in Head and Neck Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13205241
Abstract: Simple Summary Head and neck cancer is the sixth most common malignancy worldwide and it affects approximately 50,000 patients annually in the United States. Current treatments are suboptimal and induce significant long-term toxicities that permanently… read more here.
Keywords: cancer; neck cancer; epigenetic modifiers; head neck ... See more keywords
Functional Drug Screening of Small Molecule Inhibitors of Epigenetic Modifiers in Refractory AML Patients
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14174094
Abstract: Simple Summary Acute myeloid leukemia is a cancer originating in the bone marrow and peripheral blood. Genetic mutations observed with the disease are difficult to target therapeutically and patients often have different treatment responses to… read more here.
Keywords: aml patients; disease; inhibitors epigenetic; epigenetic modifiers ... See more keywords