BRD4: epigenetic origin and target of CTCL.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2017-12-820266
Abstract: In this issue of Blood , Kohnken et al demonstrate a novel oncogenic pathway featuring IL-15-miR-29b-BRD4 positive feedback loop and targeting bromodomain-containing protein 4 (BRD4) disables the oncogenic loop, identifying a potentially effective target for… read more here.
Keywords: brd4 epigenetic; ctcl; target; brd4 ... See more keywords
Rare diseases of epigenetic origin: Challenges and opportunities
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1113086
Abstract: Rare diseases (RDs), more than 80% of which have a genetic origin, collectively affect approximately 350 million people worldwide. Progress in next-generation sequencing technology has both greatly accelerated the pace of discovery of novel RDs… read more here.
Keywords: epigenetic origin; diseases epigenetic; rare diseases; challenges opportunities ... See more keywords