Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04294k
Abstract: The flexible N-terminal histone tails are a subject of numerous posttranslational modifications, including methylation. We report development of stapled histone peptides bearing trimethyllysine as ligands for epigenetic reader proteins. Stronger or weaker binding affinities have… read more here.
Keywords: epigenetic reader; histone; recognition stapled; reader proteins ... See more keywords
Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz1044
Abstract: Abstract Epigenetic regulatory mechanisms are central to the development and survival of all eukaryotic organisms. These mechanisms critically depend on the marking of chromatin domains with distinctive histone tail modifications (PTMs) and their recognition by… read more here.
Keywords: complexes human; reader; reader complexes; plasmodium falciparum ... See more keywords
The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential
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DOI: 10.3390/cimb45050269
Abstract: SP140 is an epigenetic reader protein expressed predominantly in immune cells. GWAS studies have shown an association between SP140 single nucleotide polymorphisms (SNPs) and diverse autoimmune and inflammatory diseases, suggesting a possible pathogenic role for… read more here.
Keywords: cell; maturation; epigenetic reader; expression ... See more keywords
Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25081918
Abstract: Gaining a fundamental insight into the biomolecular recognition of posttranslationally modified histones by epigenetic reader proteins is of crucial importance to understanding the regulation of the activity of human genes. Here, we seek to establish… read more here.
Keywords: trimethyllysine; reader proteins; reader; molecular recognition ... See more keywords