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Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12914
Abstract: Rhabdomyosarcoma (RMS) is an aggressive pediatric soft tissue sarcoma. There are two main subtypes of RMS, alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma. ARMS typically encompasses fusion‐positive rhabdomyosarcoma, which expresses either PAX3‐FOXO1 or PAX7‐FOXO1 fusion proteins.…
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Keywords:
epigenetic regulator;
target;
rhabdomyosarcoma;
alveolar rhabdomyosarcoma ... See more keywords
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Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22652-9
Abstract: Arginine plays diverse roles in cellular physiology. As a semi-essential amino acid, arginine deprivation has been used to target cancers with arginine synthesis deficiency. Arginine-deprived cancer cells exhibit mitochondrial dysfunction, transcriptional reprogramming and eventual cell…
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Keywords:
epigenetic regulator;
arginine;
prostate cancer;
cancer cells ... See more keywords
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Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2552-x
Abstract: During ontogeny, proliferating cells become restricted in their fate through the combined action of cell-type-specific transcription factors and ubiquitous epigenetic machinery, which recognizes universally available histone residues or nucleotides in a context-dependent manner 1 ,…
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Keywords:
single cell;
regulator function;
epigenetic regulator;
gastrulation ... See more keywords
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Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc05957f
Abstract: Here, we provide an out-of-the-box G-quadruplex (G4) targeting-based strategy for rescuing mitochondrial dysfunction in Alzheimer's disease. We predict and verify the presence of G4s within the promoter of an ageing epigenetic regulator BAZ2B. G4-specific ligands…
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Keywords:
promoter;
epigenetic regulator;
mitochondrial dysfunction;
dysfunction ... See more keywords
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Published in 2021 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001062
Abstract: ABSTRACT Enhancer of zeste homolog 2(EZH2) is an enzymatic subunit of polycomb repressive complex 2 (PRC2) and is responsible for catalyzing mono-, di-, and trimethylation of histone H3 at lysine-27(H3K27me1/2/3). Many noncoding RNAs or signaling…
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Keywords:
cardiovascular development;
development;
regulator cardiovascular;
ezh2 epigenetic ... See more keywords
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Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5069
Abstract: Epigenetic dysregulation is a common characteristic of cancer, including gastric cancer(GC), which ultimately contributes to the development and progression of GC. Sequencing of cancer genomes has revealed frequent mutations in epigenetic regulators, particularly chromatin remodelers…
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Keywords:
inhibition bet;
bet bromodomain;
gastric cancer;
epigenetic regulator ... See more keywords
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Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2907
Abstract: Gene expression frequently requires the dynamic remodelling of the chromatin architecture to orchestrate the assembly of transcriptional protein complexes at the promoter sites of DNA. Chromatin remodelling complexes are multicomponent proteins that facilitate reorganisation of…
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Keywords:
targeting epigenetic;
regulator kat2a;
epigenetic regulator;
gene expression ... See more keywords