Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23567
Abstract: During development or after brain injury, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes to supplement the number of oligodendrocytes. Although mechanisms of OPC differentiation have been extensively examined, the role of epigenetic regulators, such as… read more here.
Keywords: epigenetic regulators; differentiation; differential roles; opc differentiation ... See more keywords
Deregulation of imprinted genes expression and epigenetic regulators in placental tissue from intrauterine growth restriction
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-020-02047-3
Abstract: Purpose Intrauterine growth restriction (IUGR) is a fetal growth complication that can be caused by ineffective nutrient transfer from the mother to the fetus via the placenta. Abnormal placental development and function have been correlated… read more here.
Keywords: epigenetic regulators; restriction; methylation; imprinted genes ... See more keywords
Circular RNAs and gastrointestinal cancers: Epigenetic regulators with a prognostic and therapeutic role.
Sign Up to like & getrecommendations! Published in 2019 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2019.102854
Abstract: Both environmental and genetic factors are involved in the initiation and development of gastrointestinal cancer. Covalent closed circular RNAs (circRNAs) are produced by a mechanism called "back-splicing" from mRNAs. They are highly stable and show… read more here.
Keywords: epigenetic regulators; circular rnas; cancers epigenetic; gastrointestinal cancers ... See more keywords
Targeting Autophagy-Related Epigenetic Regulators for Cancer Drug Discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00579
Abstract: Existing evidence has demonstrated that epigenetic modifications (including DNA methylation, histone modifications, and microRNAs), which are associated with the occurrence and development of tumors, can directly or indirectly regulate autophagy. In particular, nuclear events induced… read more here.
Keywords: epigenetic regulators; targeting autophagy; epigenetic drugs; autophagic process ... See more keywords
Coexpression patterns define epigenetic regulators associated with neurological dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "Genome research"
DOI: 10.1101/gr.239442.118
Abstract: Coding variants in epigenetic regulators are emerging as causes of neurological dysfunction and cancer. However, a comprehensive effort to identify disease candidates within the human epigenetic machinery (EM) has not been performed; it is unclear… read more here.
Keywords: epigenetic regulators; associated neurological; variation; neurological dysfunction ... See more keywords
Dysregulation of the TET family of epigenetic regulators in hematopoietic malignancies.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019791475
Abstract: DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, X-chromosome inactivation and cancer. Cancer cells display highly dysregulated DNA methylation profiles characterized by global hypomethylation in conjunction with hypermethylation of promoter… read more here.
Keywords: epigenetic regulators; tet family; family epigenetic; dysregulation tet ... See more keywords
Combating castration-resistant prostate cancer by co-targeting the epigenetic regulators EZH2 and HDAC
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002038
Abstract: While screening and early detection have reduced mortality from prostate cancer, castration-resistant disease (CRPC) is still incurable. Here, we report that combined EZH2/HDAC inhibitors potently kill CRPCs and cause dramatic tumor regression in aggressive human… read more here.
Keywords: prostate cancer; ezh2 hdac; prostate; castration resistant ... See more keywords
Long Non-Coding RNAs: Epigenetic Regulators in Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Current pharmaceutical design"
DOI: 10.2174/1381612825666190830161528
Abstract: Long noncoding RNAs (lncRNAs) are the large portions of the mammalian transcriptome which is appearing as a fundamental player regulating various cellular mechanisms. LncRNAs that do not encode proteins, have mRNA-like transcripts and they are… read more here.
Keywords: epigenetic regulators; coding rnas; rnas epigenetic; long non ... See more keywords
Long Non-coding RNAs: Pivotal Epigenetic Regulators in Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Current Genomics"
DOI: 10.2174/1389202923666220531105035
Abstract: Diabetic retinopathy (DR) is a severe complication of diabetes; however, its mechanism is not fully understood. Evidence has recently revealed that long non-coding RNAs (lncRNAs) are abnormally expressed in DR, and lncRNAs may function as… read more here.
Keywords: long non; coding rnas; epigenetic regulators; diabetic retinopathy ... See more keywords
Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies
Sign Up to like & getrecommendations! Published in 2023 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v29.i7.1219
Abstract: BACKGROUND Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). However, whether the influence of methyl donor intake is modified by polymorphisms in such epigenetic regulators is still unclear. AIM To… read more here.
Keywords: influence methyl; methyl donor; crc; observational studies ... See more keywords
Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.358615
Abstract: The growing and rapid development of high-throughput sequencing technologies have allowed a greater understanding of the mechanisms underlying gene expression regulation. Editing the epigenome and epitranscriptome directs the fate of the transcript influencing the functional… read more here.
Keywords: rnas epigenetic; long noncoding; noncoding rnas; regulators neurodegenerative ... See more keywords