Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301802
Abstract: Epithelial-mesenchymal transition (EMT) is a reversible transcriptional program invoked by cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of EMT, driving disease recurrence in poor-outcome triple negative breast cancers (TNBCs). Here,… read more here.
Keywords: breast; triple negative; dcas9; zeb1 ... See more keywords
NDST3-Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202507323
Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons (DN) in the substantia nigra and disruption of cellular maintenance. Here, we demonstrate that NDST3-mediated epigenetic reprogramming halts neuronal degeneration… read more here.
Keywords: ndst3; parkinson disease; ndst3 induced; epigenetic reprogramming ... See more keywords
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.01.006
Abstract: Epigenetic modifications on DNA and histones regulate gene expression by modulating chromatin accessibility to transcription machinery. Here we identify methionine as a key nutrient affecting epigenetic reprogramming in CD4+ T helper (Th) cells. Using metabolomics,… read more here.
Keywords: metabolism shapes; methionine; methionine metabolism; epigenetic reprogramming ... See more keywords
The lncRNA MARS modulates the epigenetic reprogramming of the marneral cluster in response to ABA.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular plant"
DOI: 10.1016/j.molp.2022.02.007
Abstract: Clustered organization of biosynthetic non-homologous genes is emerging as a characteristic feature of plant genomes. The co-regulation of clustered genes seems to largely depend on epigenetic reprogramming and three-dimensional chromatin conformation. Here we identified the… read more here.
Keywords: cluster; response aba; marneral cluster; epigenetic reprogramming ... See more keywords
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26777-9
Abstract: Lung diseases, such as cystic fibrosis and COPD, are characterized by mucus obstruction and chronic airway inflammation, but their mechanistic link remains poorly understood. Here, we focus on the function of the mucostatic airway microenvironment… read more here.
Keywords: disease; obstructive lung; muco obstructive; epigenetic reprogramming ... See more keywords
Lycopene enhances epigenetic reprogramming and zygotic genome activation in the porcine somatic cell nuclear transfer embryo
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-15672-8
Abstract: Pigs are valuable models for human disease research due to their physiological similarities to humans, and somatic cell nuclear transfer (SCNT) is commonly used to generate such models. However, SCNT efficiency is limited by incomplete… read more here.
Keywords: porcine; cell nuclear; nuclear transfer; somatic cell ... See more keywords
The effect of epigenetic reprogramming using MI192 HDAC inhibitor on enhancing the osteogenesis of human adipose-derived stem cells in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Bioscience Reports"
DOI: 10.1042/bsr20221635
Abstract: Abstract The ability to control stem cell function is the key to stem cell-based therapy and living tissue regeneration. In natural conditions, histone deacetylases (HDAC) are regarded as the important defining epigenetic reprogramming for stem… read more here.
Keywords: pre treatment; human adipose; epigenetic reprogramming; stem ... See more keywords
Incomplete erasure of histone marks during epigenetic reprogramming in medaka early development.
Sign Up to like & getrecommendations! Published in 2023 at "Genome research"
DOI: 10.1101/gr.277577.122
Abstract: Epigenetic modifications undergo drastic erasure and reestablishment after fertilization. This reprogramming is required for proper embryonic development and cell differentiation. In mammals, some histone modifications are not completely reprogrammed and play critical roles in later… read more here.
Keywords: histone modifications; cleavage stage; development; epigenetic reprogramming ... See more keywords
Windows of opportunity: ocean warming shapes temperature-sensitive epigenetic reprogramming and gene expression across gametogenesis and embryogenesis in marine stickleback.
Sign Up to like & getrecommendations! Published in 2021 at "Global change biology"
DOI: 10.1111/gcb.15942
Abstract: Rapid climate change is placing many marine species at risk of local extinction. Recent studies show that epigenetic mechanisms (e.g. DNA methylation, histone modifications) can facilitate both within and transgenerational plasticity to cope with changing… read more here.
Keywords: ocean warming; temperature; temperature sensitive; expression ... See more keywords
BATF is a major driver of NK cell epigenetic reprogramming and dysfunction in AML
Sign Up to like & getrecommendations! Published in 2024 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.adp0004
Abstract: Myelodysplastic syndrome and acute myeloid leukemia (AML) belong to a continuous disease spectrum of myeloid malignancies with poor prognosis in the relapsed/refractory setting necessitating novel therapies. Natural killer (NK) cells from patients with myeloid malignancies… read more here.
Keywords: myeloid malignancies; aml; dysfunction; batf ... See more keywords
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-18-1474
Abstract: Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. We performed an integrative characterization of epigenomic and transcriptomic changes, including single-cell RNA-seq, during normal… read more here.
Keywords: epigenetic reprogramming; aging human; stem cells; hematopoietic stem ... See more keywords