Epigenetic silencing of E‐cadherin gene induced by lncRNA MALAT‐1 in acute myeloid leukaemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24556
Abstract: Epigenetic abnormalities in acute myeloid leukaemia provide us with a target for novel therapeutic strategies. The aim of the study was to verify the epigenetic regulatory mechanism of E‐cadherin gene silencing induced by long non‐coding… read more here.
Keywords: cadherin gene; acute myeloid; epigenetic silencing; myeloid leukaemia ... See more keywords
Recruitment and reinforcement: maintaining epigenetic silencing
Sign Up to like & getrecommendations! Published in 2018 at "Science China Life Sciences"
DOI: 10.1007/s11427-018-9276-7
Abstract: Cells need to appropriately balance transcriptional stability and adaptability in order to maintain their identities while responding robustly to various stimuli. Eukaryotic cells use an elegant “epigenetic” system to achieve this functionality. “Epigenetics” is referred… read more here.
Keywords: epigenetic silencing; information; maintaining epigenetic; recruitment reinforcement ... See more keywords
Layer-by-Layer Particles Deliver Epigenetic Silencing siRNA to HIV-1 Latent Reservoir Cell Types.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c01030
Abstract: For over two decades, nanomaterials have been employed to facilitate intracellular delivery of small interfering RNA (siRNA), both in vitro and in vivo, to induce post-transcriptional gene silencing (PTGS) via RNA interference. Besides PTGS, siRNAs… read more here.
Keywords: layer layer; epigenetic silencing; cell types; silencing sirna ... See more keywords
Epigenetic silencing of RIPK3 in hepatocytes prevents MLKL-mediated necroptosis from contributing to liver pathologies.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.08.040
Abstract: BACKGROUND AND AIMS Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury including steatohepatitis/NASH. However, the evidence supporting these claims has been controversial. A comprehensive, fundamental understanding… read more here.
Keywords: necroptosis; silencing ripk3; mlkl; pathology ... See more keywords
The Role of Small RNA-Based Epigenetic Silencing for Purifying Selection on Transposable Elements in Capsella grandiflora
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evx206
Abstract: Abstract To avoid negative effects of transposable element (TE) proliferation, plants epigenetically silence TEs using a number of mechanisms, including RNA-directed DNA methylation. These epigenetic modifications can extend outside the boundaries of TE insertions and… read more here.
Keywords: gene regulation; epigenetic silencing; selection; capsella grandiflora ... See more keywords
Abstract B011: PRAC1 epigenetic silencing in castration resistant prostate cancer and its novel role in androgen receptor biology
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-b011
Abstract: Background Resistance to androgen receptor (AR) directed therapies is one of the key drivers of prostate cancer mortality. Although several molecular alterations involved in castration resistant prostate cancer (CRPC) have been catalogued, a deep mechanistic… read more here.
Keywords: prostate cancer; biology; prac1; castration resistant ... See more keywords
Abstract 5223: Epigenetic silencing mediated by non-phosphorylated STAT5B prevents differentiation in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-5223
Abstract: STAT5 proteins are transcription factors involved in the regulation of proliferation, apoptosis and differentiation. Upon ligand-mediated activation, phosphorylated STAT5A (pSTAT5A) and pSTAT5B form homo- or heterodimers, translocate to the nucleus and activate transcription. Recent data… read more here.
Keywords: differentiation; aml cells; stat5b; epigenetic silencing ... See more keywords
Silencing of Mutator Elements in Maize Involves Distinct Populations of Small RNAs and Distinct Patterns of DNA Methylation.
Sign Up to like & getrecommendations! Published in 2020 at "Genetics"
DOI: 10.1534/genetics.120.303033
Abstract: Transposable elements (TEs) are a ubiquitous feature of plant genomes. Because of the threat they post to genome integrity, most TEs are epigenetically silenced. However, even closely related plant species often have dramatically different populations… read more here.
Keywords: epigenetic silencing; methylation; patterns dna; maize involves ... See more keywords
Epigenetic silencing of tumor suppressor candidate 3 confers adverse prognosis in early colorectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20950
Abstract: Colorectal cancer (CRC) is a biologically and clinically heterogeneous disease. Even though many recurrent genomic alterations have been identified that may characterize distinct subgroups, their biological impact and clinical significance as prognostic indicators remain to… read more here.
Keywords: epigenetic silencing; tumor suppressor; colorectal cancer; crc ... See more keywords
Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15061830
Abstract: Simple Summary Epithelial tissues are the most common sites for the development of cancer. Loss of epithelial cell characteristics and dedifferentiation are hallmarks of cancer. A specialized and complex function in epithelial cells is receptor-mediated… read more here.
Keywords: cell; lrp2 expression; epigenetic silencing; cancer ... See more keywords
Components from the Human c-myb Transcriptional Regulation System Reactivate Epigenetically Repressed Transgenes
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21020530
Abstract: A persistent challenge for mammalian cell engineering is the undesirable epigenetic silencing of transgenes. Foreign DNA can be incorporated into closed chromatin before and after it has been integrated into a host cell’s genome. To… read more here.
Keywords: transcriptional regulation; epigenetic silencing; system; myb transcriptional ... See more keywords