Replication timing maintains the global epigenetic state in human cells
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.aba5545
Abstract: Replication timing organizes epigenome The temporal order of DNA replication is conserved from yeast to humans, but its biological significance remains unclear. Klein et al. eliminated the protein RIF1, a master regulator of replication timing,… read more here.
Keywords: genome architecture; replication timing; replication; epigenetic state ... See more keywords
Abstract 3905: Epigenetic primming reveals the central role of epigenetic state in the anti-tumor activity of vitamin D in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3905
Abstract: Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, which is largely due to the intrinsic resistance to a broad spectrum of therapies. Vitamin D (VD) has been extensively studied as a potential preventive or therapeutic… read more here.
Keywords: anti tumor; tumor activity; ductal adenocarcinoma; epigenetic state ... See more keywords
Ready, Set…Poised!: Polycomb target genes are bound by poised RNA polymerase II throughout differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Systems Biology"
DOI: 10.15252/msb.20177968
Abstract: In embryonic stem cells (ESCs), silent genes with major developmental functions display a unique epigenetic state in which strong and broad binding by Polycomb repressive complexes (PRCs) is accompanied by the presence of poised RNA… read more here.
Keywords: epigenetic state; throughout differentiation; rna polymerase; differentiation ... See more keywords