PATH-11. PROGNOSTIC SIGNIFICANCE OF EPIGENETIC SUBTYPES AND CpGs ASSOCIATED WITH PROGRESSION TO G-CIMP LOW IN THE EORTC RANDOMIZED PHASE III INTERGROUP CATNON
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DOI: 10.1093/neuonc/noaa215.693
Abstract: Uncontrolled studies have suggested that methylation-based epigenetic subtypes can be used for prognostication of glioma. We used the prospective randomized CATNON trial to validate the clinical relevance of these epigenetic subtypes. The phase III CATNON… read more here.
Keywords: cimp; epigenetic subtypes; cimp low; idh1 2mt ... See more keywords
Abstract 1179: Epigenetic subtypes and cellular plasticity are driven by an interplay between RUNX2 and FOSL1 in osteosarcoma
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DOI: 10.1158/1538-7445.am2025-1179
Abstract: Chromatin accessibility is a crucial driver of cellular plasticity, priming gene expression and defining distinct cellular states. Variability in chromatin accessibility is a significant determinant of epigenetic transcriptional regulation and can reveal clinically relevant subtypes… read more here.
Keywords: runx2 fosl1; osteosarcoma; plasticity; cellular plasticity ... See more keywords