Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d0ra07971e
Abstract: Alteration in the pattern of epigenetic marking leads to cancer, neurological disorders, inflammatory problems etc. These changes are due to aberration in histone modification enzymes that function as readers, writers and erasers. Bromodomains (BDs) and… read more here.
Keywords: epigenetic targets; bet family; bromodomain bet; cancer ... See more keywords
Identifying epigenetic targets underlying the effects of prenatal exposure to opioids
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1111/gbb.12503
Abstract: Over the past 5 to 10 years, the opioid epidemic has become a national crisis in the United States. This emergency has led also to an increase in in utero exposure to opioids, with a… read more here.
Keywords: targets underlying; epigenetic targets; exposure opioids; exposure ... See more keywords
Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12050672
Abstract: Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease that is increasingly becoming a global threat to the health and life of the elderly worldwide. Although there are some drugs clinically available for treating PD,… read more here.
Keywords: disease; epigenetic targets; parkinson disease; histone deacetylases ... See more keywords
Epigenetic Targets and Their Inhibitors in Thyroid Cancer Treatment
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16040559
Abstract: Although biologically targeted therapies based on key oncogenic mutations have made significant progress in the treatment of locally advanced or metastatic thyroid cancer, the challenges of drug resistance are urging us to explore other potentially… read more here.
Keywords: epigenetic targets; inhibitors thyroid; thyroid cancer; treatment ... See more keywords