Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets
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DOI: 10.1038/npp.2016.203
Abstract: Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets read more here.
Keywords: therapies neuroscience; neuroscience focus; epigenetic therapies; bromodomain containing ... See more keywords
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency
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DOI: 10.1038/s41586-020-2844-1
Abstract: Cancer therapies that target epigenetic repressors can mediate their effects by activating retroelements within the human genome. Retroelement transcripts can form double-stranded RNA (dsRNA) that activates the MDA5 pattern recognition receptor 1 – 6 .… read more here.
Keywords: epigenetic therapy; viral mimicry; inverted repeat; epigenetic therapies ... See more keywords
Emerging epigenetic therapies of cardiac fibrosis and remodeling in heart failure: from basic mechanisms to early clinical development.
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DOI: 10.1093/cvr/cvac142
Abstract: Cardiovascular diseases and specifically heart failure (HF) impact global health and impose a significant economic burden on society. Despite current advances in standard of care, the risks for death and readmission of HF patients remain… read more here.
Keywords: heart failure; development; clinical development; early clinical ... See more keywords
Epigenetic therapies in acute myeloid leukemia: the role of hypomethylating agents, histone deacetylase inhibitors and the combination of hypomethylating agents with histone deacetylase inhibitors
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DOI: 10.1097/cm9.0000000000000685
Abstract: Abstract Epigenetic regulation includes changes of DNA methylation and modifications of histone proteins and is essential for normal physiologic functions, especially for controlling gene expression. Epigenetic dysregulation plays a key role in disease pathogenesis and… read more here.
Keywords: histone deacetylase; deacetylase inhibitors; hypomethylating agents; epigenetic therapies ... See more keywords
Epigenetic Therapies and Biomarkers in Breast Cancer
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DOI: 10.3390/cancers14030474
Abstract: Simple Summary Epigenetic therapies are promising agents for overcoming clinical resistance to conventional treatments in breast cancer. In the assessed trials, the use of epigenetic therapies for the management of breast cancer has not translated… read more here.
Keywords: biomarkers breast; breast cancer; management; cancer ... See more keywords
Is There a Role for Epigenetic Therapies in Modulating DNA Damage Repair Pathways to Enhance Chemotherapy and Overcome Drug Resistance?
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DOI: 10.3390/cancers14061533
Abstract: Simple Summary Epigenetic changes in a cell’s genome can cause the inactivation of genes and affect how tumours respond to chemotherapy. These epigenetic changes do not alter the DNA sequence and small molecule inhibitors of… read more here.
Keywords: dna damage; resistance; chemotherapy; epigenetic therapies ... See more keywords
Advances in Ophthalmic Epigenetics and Implications for Epigenetic Therapies: A Review
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DOI: 10.3390/genes14020417
Abstract: The epigenome represents a vast molecular apparatus that writes, reads, and erases chemical modifications to the DNA and histone code without changing the DNA base-pair sequence itself. Recent advances in molecular sequencing technology have revealed… read more here.
Keywords: therapies review; advances ophthalmic; implications epigenetic; epigenetics implications ... See more keywords