Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2017.08.007
Abstract: OBJECTIVES Aldehyde dehydrogenase 1 (ALDH1) is associated with tumorigenesis, and shown to identify cancer stem cells (CSC)-like cells. We aimed to investigate the significance of ALDH1 in oral squamous cell carcinoma (OSCC) and its correlation… read more here.
Keywords: response; aldh1; epigenetic therapy; expression ... See more keywords
Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2844-1
Abstract: Cancer therapies that target epigenetic repressors can mediate their effects by activating retroelements within the human genome. Retroelement transcripts can form double-stranded RNA (dsRNA) that activates the MDA5 pattern recognition receptor 1 – 6 .… read more here.
Keywords: epigenetic therapy; viral mimicry; inverted repeat; epigenetic therapies ... See more keywords
Effects of Epigenetic Therapy on Natural Killer Cell Function and Development in Hematologic Malignancy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad026
Abstract: Epigenetic therapy is an emerging field in the treatment of human cancer, including hematologic malignancies. This class of FDA-approved therapeutic agents for cancer treatment includes DNA hypomethylating agents, histone deacetylase inhibitors, IDH1/2 inhibitors, EZH2 inhibitors,… read more here.
Keywords: function; epigenetic therapy; development; natural killer ... See more keywords
How Epigenetic Therapy Beats Adverse Genetics in Monosomy Karyotype AML
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-4108
Abstract: The study by Greve and colleagues, in this issue of Cancer Research, provides new molecular insights into the intriguing clinical activity of DNA hypomethylating agents (HMA) in patients with acute myeloid leukemia (AML) with monosomal… read more here.
Keywords: monosomal karyotypes; therapy beats; beats adverse; aml ... See more keywords
Epigenetic Therapy Targets Th1/Th17 Polarization to Reversing Immune Evasion and Treating Leukemia Relapse Post Allogeneic Stem Cell Transplantation in Non-APL AML Patients
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-111671
Abstract: To reverse non-APL AML patients with post-transplantation relapse before hematological relapse(early-stage relapse), we investigated the safety and efficacy of a new epigenetic therapy(DNA methyltransferase inhibitors, Decitabine and histone deacetylase inhibitors, Chidamide, plus Thymalfasin simultaneously). Twenty-four… read more here.
Keywords: epigenetic therapy; relapse; th1 th17; non apl ... See more keywords
Methylation modification in gastric cancer and approaches to targeted epigenetic therapy (Review).
Sign Up to like & getrecommendations! Published in 2017 at "International journal of oncology"
DOI: 10.3892/ijo.2017.3981
Abstract: Gastric cancer (GC) is one of the most common cancers and the second leading cause of cancer-related mortality. Increasing discoveries have highlighted aberrant epigetic modifications actively contribute to the pathogenesis of this fatal disease. Among… read more here.
Keywords: methylation; gastric cancer; epigenetic therapy; targeted epigenetic ... See more keywords