Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2017.06.002
Abstract: Gliomas and leukemias remain highly refractory to treatment, thus highlighting the need for new and improved therapeutic strategies. Mutations in genes encoding enzymes involved in the tricarboxylic acid (TCA) cycle, such as the isocitrate dehydrogenases… read more here.
Keywords: activities idh1; oncogenic activities; idh1 mutations; mutations epigenetics ... See more keywords
Interplay between Epigenetics and Cellular Metabolism in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11101406
Abstract: Cellular metabolism alterations have been recognized as one of the most predominant hallmarks of colorectal cancers (CRCs). It is precisely regulated by many oncogenic signaling pathways in all kinds of regulatory levels, including transcriptional, post-transcriptional,… read more here.
Keywords: metabolism; cellular metabolism; interplay epigenetics; metabolic enzymes ... See more keywords