Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches
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DOI: 10.1038/onc.2016.485
Abstract: Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven metabolic rewiring modifies the epigenetic landscape via modulating the activities of DNA and histone modification enzymes at the metabolite level. Conversely, epigenetic mechanisms regulate… read more here.
Keywords: epigenetics metabolism; oncogenesis mechanisms; mechanisms therapeutic; metabolism ... See more keywords
Crosstalk between epigenetics and metabolism—Yin and Yang of histone demethylases and methyltransferases in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Briefings in Functional Genomics"
DOI: 10.1093/bfgp/elx001
Abstract: Abstract Histone methylation is an epigenetic modification of chromatin undergoing dynamic changes and balancing tissue-specific demands of proliferation and differentiation. In cancer, aberrant histone methylation can facilitate oncogenic and tumor suppression programs by modulating gene… read more here.
Keywords: metabolism yin; epigenetics metabolism; crosstalk epigenetics; cancer ... See more keywords
Epigenetics and Metabolism in Health and Disease
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00361
Abstract: In the next 10 years, one billion people are estimated to suffer from disabling consequences of metabolic disorders, making them the number one noncommunicable disease on a global scale by 2030. Lots of risk factors… read more here.
Keywords: epigenetics metabolism; disease; health disease; metabolic disorders ... See more keywords
Editorial: Epigenetics of metabolism, immunology and aging
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1135889
Abstract: pathway regulator (TIPRL) in cancer development, as well as the TIPRL/ protein phosphatase 2A (PP2A) axis and its epigenetic regulation. In addition,Caietal.summarizedtheinteractionsofgenetics,environmental factors, and epigenetics on knee osteoarthritis, with a focus on DNA methylation, histone… read more here.
Keywords: metabolism immunology; epigenetics metabolism; editorial epigenetics; immunology aging ... See more keywords
Epigenetics and Metabolism Reprogramming Interplay into Glioblastoma: Novel Insights on Immunosuppressive Mechanisms
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DOI: 10.3390/antiox12020220
Abstract: The central nervous system represents a complex environment in which glioblastoma adapts skillfully, unleashing a series of mechanisms suitable for its efficient development and diffusion. In particular, changes in gene expression and mutational events that… read more here.
Keywords: glioblastoma novel; glioblastoma; epigenetics metabolism; interplay glioblastoma ... See more keywords