Epigenetics and therapeutic targets in gastrointestinal malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.04.013
Abstract: Gastrointestinal (GI) malignancies account for substantial mortality and morbidity worldwide. They are generally promoted by dysregulated signal transduction and epigenetic pathways, which are controlled by specific enzymes. Recent studies demonstrated that histone deacetylases (HDACs) together… read more here.
Keywords: epigenetics therapeutic; gastrointestinal malignancies; targets gastrointestinal; therapeutic targets ... See more keywords
Epigenetics and its therapeutic potential in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Epigenomics"
DOI: 10.2217/epi-2022-0067
Abstract: It is estimated that colorectal cancer (CRC) is the leading cause of cancer-related death around the globe. 'Epigenetics' refers to changes in the chromosome rather than the DNA sequence, which may be transmitted down to… read more here.
Keywords: therapeutic potential; crc; colorectal cancer; epigenetics therapeutic ... See more keywords
Epigenetics as a Therapeutic Target in Osteoarthritis
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020156
Abstract: Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered that epigenetics may play an important… read more here.
Keywords: epigenetics therapeutic; therapeutic target; target osteoarthritis;