MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
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DOI: 10.1016/j.chembiol.2020.02.002
Abstract: Mitochondrial D2HGDH and L2HGDH catalyze the oxidation of D-2-HG and L-2-HG, respectively, into αKG. This contributes to cellular homeostasis in part by modulating the activity of αKG-dependent dioxygenases. Signals that control the expression/activity of D2HGDH/L2HGDH… read more here.
Keywords: d2hgdh; myc regulation; epigenome epitranscriptome; d2hgdh l2hgdh ... See more keywords