Estimation of a significance threshold for epigenome‐wide association studies
Sign Up to like & getrecommendations! Published in 2018 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22086
Abstract: Epigenome‐wide association studies (EWAS) are designed to characterise population‐level epigenetic differences across the genome and link them to disease. Most commonly, they assess DNA‐methylation status at cytosine‐guanine dinucleotide (CpG) sites, using platforms such as the… read more here.
Keywords: association studies; significance threshold; significance; epigenome wide ... See more keywords
Epigenome-wide association analyses of active injection drug use.
Sign Up to like & getrecommendations! Published in 2022 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2022.109431
Abstract: BACKGROUND Injection drug use (IDU) is prevalent in the US and is associated with substantial risk of blood-borne infections, morbidity, and mortality. However, the spectrum of its biologic effects on DNA methylation in blood is… read more here.
Keywords: epigenome wide; drug; drug use; injection ... See more keywords
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature20784
Abstract: Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances. Although the mechanisms linking adiposity to associated… read more here.
Keywords: methylation; adiposity; dna methylation; epigenome wide ... See more keywords
Identification of differentially methylated cell-types in Epigenome-Wide Association Studies
Sign Up to like & getrecommendations! Published in 2018 at "Nature methods"
DOI: 10.1038/s41592-018-0213-x
Abstract: An outstanding challenge of epigenome-wide association studies (EWASs) performed in complex tissues is the identification of the specific cell type(s) responsible for the observed differential DNA methylation. Here we present a statistical algorithm called CellDMC… read more here.
Keywords: methylation; differentially methylated; cell; epigenome wide ... See more keywords
Epigenome-wide Analysis Identifies Genes and Pathways Linked to Neurobehavioral Variation in Preterm Infants
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42654-4
Abstract: Neonatal molecular biomarkers of neurobehavioral responses (measures of brain-behavior relationships), when combined with neurobehavioral performance measures, could lead to better predictions of long-term developmental outcomes. To this end, we examined whether variability in buccal cell… read more here.
Keywords: analysis identifies; age; wide analysis; preterm infants ... See more keywords
Epigenome-wide association study reveals CpG sites related to COG of neuroblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20200826
Abstract: Abstract Background. Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children. Its variable location and complex pathogenesis make NB hard for early diagnosis and risk classification. Methodology. We analyzed the methylation… read more here.
Keywords: epigenome wide; association study; study; cog ... See more keywords
DNA Methylation and Ischemic Stroke Risk: An Epigenome-Wide Association Study.
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0042-1749328
Abstract: BACKGROUND Ischemic stroke (IS) risk heritability is partly explained by genetics. Other heritable factors, such as epigenetics, could explain an unknown proportion of the IS risk. The objective of this study is to evaluate DNA… read more here.
Keywords: cpg sites; epigenome wide; dna methylation; risk ... See more keywords
EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab972
Abstract: Epigenome-Wide Association Study (EWAS) has become a standard strategy to discover DNA methylation variation of different phenotypes. Since 2018, we have developed EWAS Atlas and EWAS Data Hub to integrate a growing volume of EWAS… read more here.
Keywords: knowledge; ewas open; epigenome wide; open platform ... See more keywords
Epigenome-Wide Analysis of DNA Methylation and Optimism in Women and Men
Sign Up to like & getrecommendations! Published in 2022 at "Psychosomatic Medicine"
DOI: 10.1097/psy.0000000000001147
Abstract: ABSTRACT Objective Higher optimism is associated with reduced mortality and a lower risk of age-related chronic diseases. DNA methylation (DNAm) may provide insight into mechanisms underlying these relationships. We hypothesized that DNAm would differ among… read more here.
Keywords: significantly differentially; optimism; epigenome wide; dna methylation ... See more keywords
Epigenome‐wide association studies in Alzheimer’s disease; achievements and challenges
Sign Up to like & getrecommendations! Published in 2020 at "Brain Pathology"
DOI: 10.1111/bpa.12880
Abstract: Alzheimer’s disease (AD) represents a devastating progressive neurodegenerative disease with a complex pathophysiology, affecting millions of people worldwide. Recent epigenome‐wide association studies suggest a key role for epigenetic mechanisms in its development and course. Despite… read more here.
Keywords: association studies; alzheimer disease; disease; epigenome wide ... See more keywords
Maternal pre‐pregnancy body mass index and offspring with overweight/obesity at preschool age: The possible role of epigenome‐wide DNA methylation changes in cord blood
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Obesity"
DOI: 10.1111/ijpo.12969
Abstract: Epigenome‐wide association studies have identified some DNA methylation sites associated with body mass index (BMI) or obesity. Studies in the Asian population are lacking. read more here.
Keywords: epigenome wide; dna methylation; body mass; mass index ... See more keywords