Epigenomic landscape of 5-hydroxymethylcytosine reveals its transcriptional regulation of lncRNAs in colorectal cancer
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DOI: 10.1038/bjc.2016.457
Abstract: Background:DNA methylation at the 5 position of cytosine (5mC) can be converted to 5-hydroxymethylcytosine (5hmC) by the ten–eleven translocation family. The loss of global levels of 5hmC has been regarded as a hallmark in various… read more here.
Keywords: hydroxymethylcytosine; epigenomic landscape; colorectal cancer; cancer ... See more keywords
Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
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DOI: 10.1038/s41467-020-17305-2
Abstract: How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark the fidelity of stem cell differentiation or cell programming, or interpret the pathogenicity… read more here.
Keywords: dynamic changes; epigenomic landscape; human organogenesis; developmental disorders ... See more keywords
Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues
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DOI: 10.1186/s12864-017-3813-4
Abstract: BackgroundNicotinic acetylcholine receptors (nAChRs) play an important role in cellular physiology and human nicotine dependence, and are closely associated with many human diseases including cancer. For example, previous studies suggest that nAChRs can re-wire gene… read more here.
Keywords: epigenomic landscape; nicotinic receptor; chrna4; non neuronal ... See more keywords