Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain.
Sign Up to like & getrecommendations! Published in 2022 at "GeroScience"
DOI: 10.1007/s11357-022-00537-z
Abstract: Intermittent fasting (IF) remains the most effective intervention to achieve robust anti-aging effects and attenuation of age-related diseases in various species. Epigenetic modifications mediate the biological effects of several environmental factors on gene expression; however,… read more here.
Keywords: intermittent fasting; epigenomic transcriptomic; transcriptomic analyses; integrative epigenomic ... See more keywords
Octopus-toolkit: a workflow to automate mining of public epigenomic and transcriptomic next-generation sequencing data
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky083
Abstract: Abstract Octopus-toolkit is a stand-alone application for retrieving and processing large sets of next-generation sequencing (NGS) data with a single step. Octopus-toolkit is an automated set-up-and-analysis pipeline utilizing the Aspera, SRA Toolkit, FastQC, Trimmomatic, HISAT2,… read more here.
Keywords: epigenomic transcriptomic; octopus toolkit; toolkit workflow; next generation ... See more keywords
Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo6764
Abstract: Alzheimer’s disease (AD) is a heterogeneous disorder with abnormalities in multiple biological domains. In an advanced machine learning analysis of postmortem brain and in vivo blood multi-omics molecular data (N = 1863), we integrated epigenomic,… read more here.
Keywords: epigenomic transcriptomic; alzheimer disease; proteomic metabolomic; taxonomy ... See more keywords
Dynamics of genomic, epigenomic, and transcriptomic aberrations during stepwise hepatocarcinogenesis.
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DOI: 10.1158/0008-5472.can-19-0991
Abstract: Hepatocellular carcinoma (HCC) undergoes a stepwise progression from liver cirrhosis (LC) to low-grade dysplastic nodule (LGDN), high-grade dysplastic nodule (HGDN), early HCC (eHCC), and progressed HCC (pHCC). Here, we profiled multi-layered genomic, epigenomic, and transcriptomic… read more here.
Keywords: genomic epigenomic; transcriptomic aberrations; epigenomic transcriptomic; hepatocarcinogenesis ... See more keywords
Epigenomic and Transcriptomic Prioritization of Candidate Obesity-Risk Regulatory GWAS SNPs
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DOI: 10.3390/ijms23031271
Abstract: Concern about rising rates of obesity has prompted searches for obesity-related single nucleotide polymorphisms (SNPs) in genome-wide association studies (GWAS). Identifying plausible regulatory SNPs is very difficult partially because of linkage disequilibrium. We used an… read more here.
Keywords: gwas; tier snps; obesity; snps ... See more keywords