Tolerability of Antiseizure Medications in Individuals With Newly Diagnosed Epilepsy.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2020.0032
Abstract: Importance Tolerability is a key determinant of the effectiveness of epilepsy treatment. It is important to evaluate whether the overall tolerability has improved. Objective To identify factors associated with poor tolerability of antiseizure medications (ASMs)… read more here.
Keywords: epilepsy; newly diagnosed; tolerability antiseizure; tolerability ... See more keywords
Association Between Standardized Mortality Ratio and Utilization of Care in US Veterans With Drug-Resistant Epilepsy Compared With All US Veterans and the US General Population.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.2290
Abstract: Importance Drug-resistant epilepsy (DRE) is thought to be associated with increased mortality, but larger population-based studies are lacking. Additionally, the benefit of effective management in DRE lacks evidence. Objective To examine the association of utilization… read more here.
Keywords: neurology; general population; veterans dre; mortality ... See more keywords
Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2022.5648
Abstract: Importance Despite advances in the understanding of dietary therapies in children with drug-resistant epilepsy, no quantitative comparison exists between different dietary interventions. Objective To evaluate the comparative efficacy and safety of various dietary therapies in… read more here.
Keywords: dietary therapies; drug resistant; efficacy safety; epilepsy ... See more keywords
Is a microRNA‐328 binding site in PAX6 associated with Rolandic epilepsy?
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DOI: 10.1002/acn3.401
Abstract: Is a microRNA-328 binding site in PAX6 associated with Rolandic epilepsy? Amelia McGlade, Kenneth A. Myers, Samuel F. Berkovic, Ingrid E. Scheffer, Slav e Petrovski & Michael S. Hildebrand* Epilepsy Research Centre, Department of Medicine,… read more here.
Keywords: epilepsy; medicine; microrna 328; site pax6 ... See more keywords
Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism
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DOI: 10.1002/acn3.51173
Abstract: The RNS System is not approved in patients under 18, although a critical need for novel treatment modalities in this vulnerable population persist. We present two pediatric patients with drug‐resistant epilepsy secondary to Lennox‐Gastaut Syndrome… read more here.
Keywords: epilepsy; autism; lennox gastaut; responsive neurostimulation ... See more keywords
Assessing the role of rare genetic variants in drug‐resistant, non‐lesional focal epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51374
Abstract: Resistance to antiseizure medications (ASMs) is one of the major concerns in the treatment of epilepsy. Despite the increasing number of ASMs available, the proportion of individuals with drug‐resistant epilepsy remains unchanged. In this study,… read more here.
Keywords: epilepsy; role rare; genetic variants; drug resistant ... See more keywords
Drug repositioning in epilepsy reveals novel antiseizure candidates
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.703
Abstract: Epilepsy treatment falls short in ~30% of cases. A better understanding of epilepsy pathophysiology can guide rational drug development in this difficult to treat condition. We tested a low‐cost, drug‐repositioning strategy to identify candidate epilepsy… read more here.
Keywords: epilepsy; drug repositioning; epilepsy reveals; reveals novel ... See more keywords
Slower alpha rhythm associates with poorer seizure control in epilepsy
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DOI: 10.1002/acn3.710
Abstract: Slowing and frontal spread of the alpha rhythm have been reported in multiple epilepsy syndromes. We investigated whether these phenomena are associated with seizure control. read more here.
Keywords: epilepsy; seizure control; alpha rhythm;
Tailoring epilepsy surgery with fast ripples in the intraoperative electrocorticogram
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DOI: 10.1002/ana.24928
Abstract: Intraoperative electrocorticography (ECoG) can be used to delineate the resection area in epilepsy surgery. High‐frequency oscillations (HFOs; 80–500 Hz) seem better biomarkers for epileptogenic tissue than spikes. We studied how HFOs and spikes in combined… read more here.
Keywords: epilepsy; fast ripples; tailoring epilepsy; epilepsy surgery ... See more keywords
Mutations in MICAL‐1cause autosomal‐dominant lateral temporal epilepsy
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DOI: 10.1002/ana.25167
Abstract: Autosomal‐dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy characterized by auditory symptoms. Two genes, LGI1 and RELN, encoding secreted proteins, are implicated in the etiology of ADLTE, but half of the affected families… read more here.
Keywords: epilepsy; dominant lateral; lateral temporal; temporal epilepsy ... See more keywords
Surgical resection of ripple onset predicts outcome in pediatric epilepsy
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DOI: 10.1002/ana.25295
Abstract: In patients with medically refractory epilepsy (MRE), interictal ripples (80–250Hz) are observed in large brain areas whose resection may be unnecessary for seizure freedom. This limits their utility as epilepsy biomarkers for surgery. We assessed… read more here.
Keywords: epilepsy; surgical resection; resection ripple; ripple onset ... See more keywords