Tolerability of Antiseizure Medications in Individuals With Newly Diagnosed Epilepsy.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2020.0032
Abstract: Importance Tolerability is a key determinant of the effectiveness of epilepsy treatment. It is important to evaluate whether the overall tolerability has improved. Objective To identify factors associated with poor tolerability of antiseizure medications (ASMs)… read more here.
Keywords: epilepsy; newly diagnosed; tolerability antiseizure; tolerability ... See more keywords
Association Between Standardized Mortality Ratio and Utilization of Care in US Veterans With Drug-Resistant Epilepsy Compared With All US Veterans and the US General Population.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.2290
Abstract: Importance Drug-resistant epilepsy (DRE) is thought to be associated with increased mortality, but larger population-based studies are lacking. Additionally, the benefit of effective management in DRE lacks evidence. Objective To examine the association of utilization… read more here.
Keywords: neurology; general population; veterans dre; mortality ... See more keywords
Brain Networks for Cortical Atrophy and Responsive Neurostimulation in Temporal Lobe Epilepsy.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2024.2952
Abstract: Importance Drug-resistant temporal lobe epilepsy (TLE) has been associated with hippocampal pathology. Most surgical treatment strategies, including resection and responsive neurostimulation (RNS), focus on this disease epicenter; however, imaging alterations distant from the hippocampus, as… read more here.
Keywords: responsive neurostimulation; brain; pathology; epilepsy ... See more keywords
Antiseizure Medications and Cardiovascular Events in Older People With Epilepsy.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2024.3210
Abstract: Importance How epilepsy may promote cardiovascular disease remains poorly understood. Objective To estimate the odds of new-onset cardiovascular events (CVEs) over 6 years in older people with vs without epilepsy, exploring how enzyme-inducing antiseizure medications… read more here.
Keywords: cohort; new onset; history; epilepsy ... See more keywords
Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks: A MELD Study.
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DOI: 10.1001/jamaneurol.2024.5406
Abstract: Importance A leading cause of surgically remediable, drug-resistant focal epilepsy is focal cortical dysplasia (FCD). FCD is challenging to visualize and often considered magnetic resonance imaging (MRI) negative. Existing automated methods for FCD detection are… read more here.
Keywords: detection; sensitivity specificity; graph neural; epilepsy ... See more keywords
Risk Factors Associated With Late-Onset Epilepsy in Dementia and Mild Cognitive Impairment.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2025.0552
Abstract: Importance The risk of developing epilepsy substantially increases after the age of 60 years (late-onset epilepsy [LOE]), particularly in people with cognitive decline ([PWCD] ie, dementia and/or mild cognitive impairment). Epilepsy is associated with worse… read more here.
Keywords: age; dementia; pwcd; risk ... See more keywords
Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2022.5648
Abstract: Importance Despite advances in the understanding of dietary therapies in children with drug-resistant epilepsy, no quantitative comparison exists between different dietary interventions. Objective To evaluate the comparative efficacy and safety of various dietary therapies in… read more here.
Keywords: dietary therapies; drug resistant; efficacy safety; epilepsy ... See more keywords
Is a microRNA‐328 binding site in PAX6 associated with Rolandic epilepsy?
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DOI: 10.1002/acn3.401
Abstract: Is a microRNA-328 binding site in PAX6 associated with Rolandic epilepsy? Amelia McGlade, Kenneth A. Myers, Samuel F. Berkovic, Ingrid E. Scheffer, Slav e Petrovski & Michael S. Hildebrand* Epilepsy Research Centre, Department of Medicine,… read more here.
Keywords: epilepsy; medicine; microrna 328; site pax6 ... See more keywords
Centromedian thalamic responsive neurostimulation for Lennox‐Gastaut epilepsy and autism
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DOI: 10.1002/acn3.51173
Abstract: The RNS System is not approved in patients under 18, although a critical need for novel treatment modalities in this vulnerable population persist. We present two pediatric patients with drug‐resistant epilepsy secondary to Lennox‐Gastaut Syndrome… read more here.
Keywords: epilepsy; autism; lennox gastaut; responsive neurostimulation ... See more keywords
Assessing the role of rare genetic variants in drug‐resistant, non‐lesional focal epilepsy
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DOI: 10.1002/acn3.51374
Abstract: Resistance to antiseizure medications (ASMs) is one of the major concerns in the treatment of epilepsy. Despite the increasing number of ASMs available, the proportion of individuals with drug‐resistant epilepsy remains unchanged. In this study,… read more here.
Keywords: epilepsy; role rare; genetic variants; drug resistant ... See more keywords
High‐Fat and Low‐Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence
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DOI: 10.1002/acn3.70017
Abstract: Dietary manipulations like ketogenic diets are established interventions for recalcitrant epilepsy. However, it remains unknown whether specific macronutrient exposure through dietary environments could possibly extend to primary preventive qualities, associated with changes in epilepsy disease… read more here.
Keywords: dietary environments; epilepsy; idiopathic epilepsy; incidence ... See more keywords