Potential Pleiotropic Genes and Shared Biological Pathways in Epilepsy and Depression Based on GWAS Summary Statistics
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DOI: 10.1155/2022/6799285
Abstract: Current epidemiological and experimental studies have indicated the overlapping genetic foundation of epilepsy and depression. However, the detailed pleiotropic genetic etiology and neurobiological pathways have not been well understood, and there are many variants with… read more here.
Keywords: pleiotropic; depression; analysis; gene ... See more keywords
Directionality of the Association Between Epilepsy and Depression
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DOI: 10.1212/wnl.0000000000201542
Abstract: Background and Objectives Epilepsy and depression share a bidirectional relationship; however, its magnitude and long-term temporal association remain to be elucidated. This study investigates the magnitude and long-term association between epilepsy and depression, comparing with… read more here.
Keywords: diagnosis; depression; risk; epilepsy ... See more keywords
Epilepsy and Depression
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DOI: 10.1212/wnl.0000000000207070
Abstract: When 2 medical conditions occur together more often than predicted by chance, they are called comorbid conditions. The observation that depression is connected to epilepsy (i.e., that they are comorbidities) raises many questions. How are… read more here.
Keywords: epilepsy depression; depression epilepsy; depression;
Comorbid epilepsy and depression—pharmacokinetic and pharmacodynamic drug interactions
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DOI: 10.3389/fphar.2022.988716
Abstract: Background: Major depressive disorder may be encountered in 17% of patients with epilepsy and in patients with drug-resistant epilepsy its prevalence may reach 30%. This indicates that patients with epilepsy may require antidepressant treatment. Purpose:… read more here.
Keywords: depression pharmacokinetic; pharmacology; antidepressant drugs; comorbid epilepsy ... See more keywords
Elevated Serum Cortisol Levels in Patients with Focal Epilepsy, Depression, and Comorbid Epilepsy and Depression
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DOI: 10.3390/ijms231810414
Abstract: Background: The hypothalamic-pituitary-adrenal (HPA) axis, inflammatory processes and neurotrophic factor systems are involved in pathogenesis of both epilepsy and depressive disorders. The study aimed to explore these systems in patients with focal epilepsy (PWE, n… read more here.
Keywords: serum cortisol; depression; pwe; pwmdd ... See more keywords