Evolving targets for anti-epileptic drug discovery.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173582
Abstract: Epilepsy is a neurological disorder that affects almost 70 million people worldwide of all socioeconomic groups. The currently available medications aim to restore the balance between excitatory and inhibitory neurotransmitters by acting on ion channels,… read more here.
Keywords: drug discovery; epileptic drug; anti epileptic; targets anti ... See more keywords
Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.881933
Abstract: Synaptic vesicle glycoprotein 2A (SV2A) regulates action potential-dependent neurotransmitter release and is commonly known as the primary binding site of an approved anti-epileptic drug, levetiracetam. Although several rodent knockout models have demonstrated the importance of… read more here.
Keywords: connectivity; epileptic drug; sv2a; epilepsy ... See more keywords
Sensing the Anti-Epileptic Drug Perampanel with Paper-Based Spinning SERS Substrates
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules27010030
Abstract: The applications of SERS in therapeutic drug monitoring, or other fields of analytical chemistry, require the availability of sensitive sensors and experimental approaches that can be implemented in affordable ways. In this contribution, we show… read more here.
Keywords: anti epileptic; paper; drug; sensing anti ... See more keywords