Long‐term ANT‐DBS effects in pilocarpine‐induced epileptic rats: A combined 9.4T MRI and histological study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25169
Abstract: Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) appears to be effective against seizures in animals and humans however, its therapeutic mechanisms remain elusive. This study aimed to combine 9.4T multimodal… read more here.
Keywords: epileptic rats; long term; dbs; ant dbs ... See more keywords
Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-018-1238-4
Abstract: Cognitive impairment is a common comorbidity in patients with temporal lobe epilepsy (TLE) that severely affects patients’ quality of life. Also, serotonin 5-hydroxytryptamine 6 (5-HT6) receptor plays an important role in cognition. This study aimed… read more here.
Keywords: learning memory; epileptic rats; ht6 receptor;
Investigation of the mechanism of tanshinone IIA to improve cognitive function via synaptic plasticity in epileptic rats
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DOI: 10.1080/13880209.2022.2157843
Abstract: Abstract Context Tanshinone IIA is an extract of Salvia miltiorrhiza Bunge (Labiatae) used to treat cardiovascular disorders. It shows potential anticonvulsant and cognition-protective properties. Objective We investigated the mechanism of tanshinone IIA on antiepileptic and… read more here.
Keywords: epileptic rats; tanshinone iia; model; iia ... See more keywords
Modulation of GABAB receptors in the insula bidirectionally affects associative memory of epilectic rats in both spatial and non-spatial operant tasks
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.1042227
Abstract: Background Stimulation of gamma-aminobutyric acid (GABA) activity through GABA receptor agonists is the basic mechanism of many anticonvulsant drugs. Nevertheless, many of these GABergic drugs have adverse cognitive effects. We previously found that GABAB receptors… read more here.
Keywords: epileptic rats; operant tasks; spatial operant; associative memory ... See more keywords
Inhibition of p38 MAPK Signaling Regulates the Expression of EAAT2 in the Brains of Epileptic Rats
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2018.00925
Abstract: Seizures induce the release of excitatory amino acids (EAAs) from the intracellular fluid to the extracellular fluid, and the released EAAs primarily comprise glutamic acid (Glu) and asparaginic acid (Asp). Glu neurotransmission functions via EAA… read more here.
Keywords: p38 mapk; eaat2 expression; mapk signaling; epileptic rats ... See more keywords
Anticonvulsant Effect of Carbenoxolone on Chronic Epileptic Rats and Its Mechanism Related to Connexin and High-Frequency Oscillations
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.870947
Abstract: Objective This study was designed to investigate the influence and mechanism of gap junction carbenoxolone (CBX) on dynamic changes in the spectral power of ripples and fast ripples (FRs) in the hippocampus of chronic epileptic… read more here.
Keywords: epileptic rats; spectral power; pilo group; expression ... See more keywords
Neuroprotection of cannabidiol in epileptic rats: Gut microbiome and metabolome sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.1028459
Abstract: Aims Epilepsy is a neurological disease occurring worldwide. Alterations in the gut microbial composition may be involved in the development of Epilepsy. The study aimed to investigate the effects of cannabidiol (CBD) on gut microbiota… read more here.
Keywords: epileptic rats; neuroprotection cannabidiol; group; cbd ... See more keywords
Blockade of TASK-1 Channel Improves the Efficacy of Levetiracetam in Chronically Epileptic Rats
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DOI: 10.3390/biomedicines10040787
Abstract: Tandem of P domains in a weak inwardly rectifying K+ channel (TWIK)-related acid sensitive K+-1 channel (TASK-1) is an outwardly rectifying K+ channel that acts in response to extracellular pH. TASK-1 is upregulated in the… read more here.
Keywords: epileptic rats; blockade task; lev; non responders ... See more keywords
Astragalus polysaccharide relieves reproductive toxicity in phenobarbital-treated epileptic rats
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DOI: 10.4314/tjpr.v17i5.9
Abstract: Purpose : To investigate the underlying mechanisms by which Astragalus polysaccharide (APS) relieves the reproductive toxicity induced by phenobarbital (PB) treatment in epileptic rats. Methods : Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay kits… read more here.
Keywords: relieves reproductive; treated epileptic; epileptic rats; astragalus polysaccharide ... See more keywords