A Role for Insulin‐like Growth Factor 1 in the Generation of Epileptic Spasms in a murine model
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26383
Abstract: Infantile spasms are associated with a wide variety of clinical conditions, including perinatal brain injuries. We have created a model in which prolonged infusion of tetrodotoxin (TTX) into the neocortex, beginning in infancy, produces a… read more here.
Keywords: model; epileptic spasms; growth factor; role ... See more keywords
Efficacy of vigabatrin in the treatment of infantile epileptic spasms syndrome: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia Open"
DOI: 10.1002/epi4.12703
Abstract: This systematic review and meta‐analysis aimed to evaluate the efficacy of vigabatrin (VGB) in treating infantile epileptic spasms syndrome (IESS). Databases of PubMed, Embase, Web of Science, MEDLINE, and Cochrane Library were systematically searched. All… read more here.
Keywords: vgb; monotherapy; epileptic spasms; meta analysis ... See more keywords
Hospital readmissions in children with new‐onset infantile epileptic spasms syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia Open"
DOI: 10.1002/epi4.12711
Abstract: To describe inpatient resource use in the 2 years following infantile epileptic spasms syndrome (IESS) diagnosis, examine the association between clinical/demographic variables and incidence of readmission, and identify risk factors/reasons for frequent readmissions. read more here.
Keywords: infantile epileptic; readmissions children; spasms syndrome; hospital readmissions ... See more keywords
Epileptic spasms secondary to acute cerebral and cerebellar encephalitis
Sign Up to like & getrecommendations! Published in 2018 at "Brain and Development"
DOI: 10.1016/j.braindev.2017.11.006
Abstract: BACKGROUND Patients with infection-related acute encephalitis sometimes develop epilepsy in the chronic phase of the disease. Patients with postencephalitic epilepsy usually develop partial seizures due to the lesions generated by the encephalitis. We report a… read more here.
Keywords: acute cerebral; months onset; epileptic spasms; encephalitis ... See more keywords
AQB-565 shows promise in preclinical testing in the model of epileptic spasms during infancy: Head-to-head comparison with ACTH
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2019.03.004
Abstract: Epileptic spasms during infancy (infantile spasms) represent a serious treatment and social problem despite their rare occurrence. Current treatments include hormonal therapy (adrenocorticotropin-ACTH or corticosteroids) or vigabatrin (per se or in the combination). These treatments… read more here.
Keywords: spasms infancy; infantile spasms; epileptic spasms; aqb 565 ... See more keywords
The Fault in Their Stars-Accumulating Astrocytic Inclusions Associated With Clusters of Epileptic Spasms in Children With Global Developmental Delay.
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric neurology"
DOI: 10.1016/j.pediatrneurol.2017.04.010
Abstract: BACKGROUND The presence of cerebral astrocytic inclusions recently has been described in a subset of children with early-onset refractory epilepsy, with or without structural brain malformations, and varying degrees of developmental delay. METHODS We describe… read more here.
Keywords: developmental delay; epileptic spasms; clusters epileptic; astrocytic inclusions ... See more keywords
Vigabatrin-related adverse events for the treatment of epileptic spasms: systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2020.1840356
Abstract: ABSTRACT Objective: Although vigabatrin (VGB) is effective and well tolerated for the treatment of epileptic spasms, there are safety concerns. The aim of this systematic review and metaanalysis was to assess adverse events of VGB… read more here.
Keywords: epileptic spasms; systematic review; treatment epileptic; adverse events ... See more keywords
Epileptic spasms are associated with increased stereo‐electroencephalography derived functional connectivity in tuberous sclerosis complex
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17353
Abstract: Epileptic spasms (ES) are common in tuberous sclerosis complex (TSC). However, the underlying network alterations and relationship with epileptogenic tubers are poorly understood. We examined interictal functional connectivity (FC) using stereo‐electroencephalography (SEEG) in patients with… read more here.
Keywords: stereo electroencephalography; functional connectivity; epileptic spasms; tuberous sclerosis ... See more keywords
Neurobehavioral deficits and a progressive ictogenesis in the tetrodotoxin model of epileptic spasms
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17428
Abstract: Our goal was to determine whether animals with a history of epileptic spasms have learning and memory deficits. We also used continuous (24/7) long‐term electroencephalographic (EEG) recordings to evaluate the evolution of epileptiform activity in… read more here.
Keywords: deficits progressive; progressive ictogenesis; tetrodotoxin model; neurobehavioral deficits ... See more keywords
Epileptic Spasms in CDKL5 Deficiency Disorder: Delayed Treatment and Poor Response to First-line Therapies.
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17630
Abstract: OBJECTIVE We aimed to assess treatment response of infantile-onset epileptic spasms (ES) in CDKL5 Deficiency Disorder (CDD) vs. other etiologies. METHODS We evaluated patients with ES from the CDKL5 Centers of Excellence and the National… read more here.
Keywords: response; cdkl5 deficiency; spasms cdkl5; treatment ... See more keywords
Epileptic Spasms Predict Poor Epilepsy Outcomes After Perinatal Stroke
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Child Neurology"
DOI: 10.1177/0883073819863278
Abstract: Perinatal stroke is a significant cause of severe epilepsy, including epileptic spasms. Although epileptic spasms due to underlying structural lesion often respond poorly to treatment and evolve into drug-resistant epilepsy, outcomes are not uniformly poor,… read more here.
Keywords: epilepsy; spasms predict; epilepsy outcomes; epileptic spasms ... See more keywords