Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2021.3310
Abstract: Importance Network hyperexcitability may contribute to cognitive dysfunction in patients with Alzheimer disease (AD). Objective To determine the ability of the antiseizure drug levetiracetam to improve cognition in persons with AD. Design, Setting, and Participants… read more here.
Keywords: trial; alzheimer disease; levetiracetam; epileptiform activity ... See more keywords
Epileptiform activity predicts epileptogenesis in cerebral hemorrhage
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51637
Abstract: This retrospective case–controlled study was performed to evaluate whether Epileptiform Activity, suspected clinical seizures, and/or 2HELPS2B/S after nontraumatic Intraparenchymal Hemorrhage or Subarachnoid Hemorrhage can predict Epilepsy. Hundred and thirty‐two patients were included—29 (Epilepsy), 103 (Control… read more here.
Keywords: hemorrhage; epileptiform activity; activity predicts; activity ... See more keywords
Enhanced responses to somatostatin interneuron activation in developmentally malformed cortex
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsia Open"
DOI: 10.1002/epi4.12316
Abstract: Intractable epilepsy is commonly associated with developmental cortical malformations. Using the rodent freeze lesion model, we have sought the underlying circuit abnormalities contributing to the epileptiform activity that occurs in association with the structural pathology… read more here.
Keywords: epileptiform activity; pmr cortex; activation; cortex ... See more keywords
Changes to gamma-aminobutyric acid levels during short-term epileptiform activity in a kainic acid-induced rat model of status epilepticus: A chemical exchange saturation transfer imaging study
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.04.010
Abstract: PURPOSE To evaluate temporal changes in gamma-aminobutyric acid (GABA) signals in the hippocampus during epileptiform activity induced by kainic acid (KA) in a rat model of status epilepticus using chemical exchange saturation transfer (CEST) imaging… read more here.
Keywords: epileptiform activity; injection; acid; rat model ... See more keywords
Artificial neural network trained on smartphone behavior can trace epileptiform activity in epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102538
Abstract: Summary A range of abnormal electrical activity patterns termed epileptiform discharges can occur in the brains of persons with epilepsy. These epileptiform discharges can be monitored and recorded with implanted devices that deliver therapeutic neurostimulation.… read more here.
Keywords: neural network; smartphone; epileptiform activity; artificial neural ... See more keywords
Focal Suppression of Epileptiform Activity in the Hippocampus by a High-frequency Magnetic Field
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.02.018
Abstract: Electric current has been used for epilepsy treatment by targeting specific neural circuitries. Despite its success, direct contact between the electrode and tissue could cause side effects including pain, inflammation, and adverse biological reactions. Magnetic… read more here.
Keywords: high frequency; frequency; field; epileptiform activity ... See more keywords
Differential association of subtypes of epileptiform activity with outcome after cardiac arrest.
Sign Up to like & getrecommendations! Published in 2019 at "Resuscitation"
DOI: 10.1016/j.resuscitation.2018.11.022
Abstract: BACKGROUND Epileptiform activity is common after cardiac arrest, although intensity of electroencephalographic (EEG) monitoring may affect detection rates. Prior work has grouped these patterns together as "malignant," without considering discrete subtypes. We describe the incidence… read more here.
Keywords: cardiac arrest; epileptiform activity; differential association; eeg ... See more keywords
Increased susceptibility to cortical spreading depression and epileptiform activity in a mouse model for FHM2
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35285-8
Abstract: Migraine is a highly prevalent, debilitating, episodic headache disorder affecting roughly 15% of the population. Familial hemiplegic migraine type 2 (FHM2) is a rare subtype of migraine caused by mutations in the ATP1A2 gene, encoding… read more here.
Keywords: fhm2; increased susceptibility; epileptiform activity; mouse model ... See more keywords
SQNN: a spike-wave index quantification neural network with a pre-labeling algorithm for epileptiform activity identification and quantification in children
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/ac542e
Abstract: Objective. Electrical status epilepticus during slow sleep (ESES) is a phenomenon identified by strong activation of epileptiform activity in the electroencephalogram (EEG) during sleep. For children disturbed by ESES, spike-wave index (SWI) is defined to… read more here.
Keywords: swi; quantification; epileptiform activity; spike wave ... See more keywords
Brivaracetam prevents the development of epileptiform activity when administered early after cortical neurotrauma in rats
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17167
Abstract: There is no effective therapy to prevent the development of posttraumatic epilepsy (PTE). Recently, we reported that administration of the antiseizure medication (ASM) levetiracetam (LEV) shortly after trauma prevented the development of epileptiform activity in… read more here.
Keywords: brivaracetam prevents; development epileptiform; development; epileptiform activity ... See more keywords
Febrile seizures lead to prolonged epileptiform activity and hyperoxia that when blocked prevents learning deficits
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17371
Abstract: In adult brain tissue, oxygen levels typically remain in the normoxic zone, but status epilepticus results in hyperoxia, whereas brief self‐terminating seizures lead to postictal hypoxia. The dynamic changes in oxygen levels and the underlying… read more here.
Keywords: activity hyperoxia; epileptiform activity; lead prolonged; seizures lead ... See more keywords