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   Articles with "epileptiform discharges" as a keyword



Intermittent fasting reduces interictal epileptiform discharges and hippocampal reactive astrogliosis during electrical kindling epileptogenesis

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recommendations! Published in 2025 at "Metabolic Brain Disease"

DOI: 10.1007/s11011-025-01607-9

Abstract: It has been proposed that interictal epileptiform discharges observed in epilepsy-related structures, such as the hippocampus contributes to epileptogenesis. Intermittent fasting (IF) produces anticonvulsant effects protecting against experimentally induced seizures. It has been suggested that… read more here.

Keywords: interictal epileptiform; electrical kindling; intermittent fasting; epileptiform discharges ... See more keywords

Inhibition of microRNA-34a Suppresses Epileptiform Discharges Through Regulating Notch Signaling and Apoptosis in Cultured Hippocampal Neurons

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recommendations! Published in 2019 at "Neurochemical Research"

DOI: 10.1007/s11064-019-02772-x

Abstract: Epilepsy is characterized by recurrent unprovoked seizures and some seizures can cause neuronal apoptosis, which is possible to make contributions to the epilepsy phenotype, impairments in cognitive function or even epileptogenesis. Moreover, many studies have… read more here.

Keywords: apoptosis; notch signaling; epileptiform discharges; regulating notch ... See more keywords

The influence of the abundance and morphology of epileptiform discharges on diagnostic accuracy: How many spikes you need to spot in an EEG

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recommendations! Published in 2021 at "Clinical Neurophysiology"

DOI: 10.1016/j.clinph.2021.03.045

Abstract: OBJECTIVE The operational definition of interictal epileptiform discharges (IEDs) of the International Federation of Clinical Neurophysiology (IFCN) described six morphological criteria. Our objective was to assess the impact of pattern-repetition in the EEG-recording, on the… read more here.

Keywords: accuracy; diagnostic accuracy; morphology; epileptiform discharges ... See more keywords
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Effect of priming low-frequency magnetic fields on zero-Mg2+ -induced epileptiform discharges in rat hippocampal slices

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recommendations! Published in 2020 at "Epilepsy Research"

DOI: 10.1016/j.eplepsyres.2020.106464

Abstract: During the process of seizures, the addition of low-frequency magnetic fields has been proved to be an effective method to suppress epileptic discharges. However, whether adding magnetic fields before the appearance of epileptic discharges can… read more here.

Keywords: magnetic fields; frequency magnetic; frequency; hippocampal slices ... See more keywords

Artificial neural network trained on smartphone behavior can trace epileptiform activity in epilepsy

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recommendations! Published in 2021 at "iScience"

DOI: 10.1016/j.isci.2021.102538

Abstract: Summary A range of abnormal electrical activity patterns termed epileptiform discharges can occur in the brains of persons with epilepsy. These epileptiform discharges can be monitored and recorded with implanted devices that deliver therapeutic neurostimulation.… read more here.

Keywords: neural network; smartphone; epileptiform activity; artificial neural ... See more keywords

Camphor elicits epileptiform discharges in snail neurons: The role of ion channels modulation

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recommendations! Published in 2017 at "Neurotoxicology"

DOI: 10.1016/j.neuro.2015.12.012

Abstract: HIGHLIGHTSThe effects of camphor on the activity of snail neurons were studied.CAM (0.25 mM) reduced afterhyperpolarization duration and disrupted firing precision.CAM (0.5 mM) suppressed falling phase and AHP and increased the firing rate.CAM (1.5 mM)… read more here.

Keywords: camphor; ion channels; ion; epileptiform discharges ... See more keywords

The relationship between epileptiform discharges and background activity in the visual analysis of electroencephalographic examinations in dogs with seizures of different etiologies.

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recommendations! Published in 2017 at "Veterinary journal"

DOI: 10.1016/j.tvjl.2017.03.003

Abstract: Electroencephalographic (EEG) recordings in 125 outpatient dogs with various epileptiform encephalopathies were acquired under medetomidine sedation using subdermal wire electrodes. The features of canine EEG (background activity [BGA] and epileptiform discharges [EDs]) were assessed, described… read more here.

Keywords: analysis; background activity; group; epileptiform discharges ... See more keywords

Transplanting GABAergic Neurons Differentiated from Neural Stem Cells into Hippocampus Inhibits Seizures and Epileptiform Discharges in Pilocarpine-Induced Temporal Lobe Epilepsy Model.

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recommendations! Published in 2019 at "World neurosurgery"

DOI: 10.1016/j.wneu.2019.01.245

Abstract: OBJECTIVE This study aimed to explore whether intrahippocampal transplantation of GABAergic neurons generated in vitro ameliorated seizures and epileptiform discharges via increasing γ-aminobutyric acid (GABA)-associated inhibition mediated by the addition of new GABAergic neurons. METHODS Neural… read more here.

Keywords: group; gaba group; epileptiform discharges; seizures epileptiform ... See more keywords

Multisensory flicker modulates widespread brain networks and reduces interictal epileptiform discharges

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-47263-y

Abstract: Modulating brain oscillations has strong therapeutic potential. Interventions that both non-invasively modulate deep brain structures and are practical for chronic daily home use are desirable for a variety of therapeutic applications. Repetitive audio-visual stimulation, or… read more here.

Keywords: brain; epileptiform discharges; flicker; interictal epileptiform ... See more keywords

Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans.

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recommendations! Published in 2025 at "Nature communications"

DOI: 10.1038/s41467-025-66562-6

Abstract: Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation. Despite extensive characterization in rodents, their detection in humans is limited by coarse spatial sampling, interictal epileptiform discharges (IEDs), and a lack of consensus… read more here.

Keywords: wave ripples; epileptiform discharges; interictal epileptiform; sharp wave ... See more keywords

Low-intensity ultrasound suppresses low-Mg2+-induced epileptiform discharges in juvenile mouse hippocampal slices.

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recommendations! Published in 2019 at "Journal of neural engineering"

DOI: 10.1088/1741-2552/ab0b9a

Abstract: OBJECTIVE It has been shown that low-intensity ultrasound (LIUS) can suppress seizures in some laboratory studies. However, the mechanism of the suppression effect of LIUS remains unclear. The goal of this study is to investigate… read more here.

Keywords: hippocampal slices; intensity ultrasound; epileptiform discharges; mouse hippocampal ... See more keywords