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   Articles with "epileptogenesis" as a keyword



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Toll‐like Receptor 4 Signaling in Neurons Enhances Calcium‐Permeable AMPA Receptor Currents and Drives Post‐Traumatic Epileptogenesis

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recommendations! Published in 2020 at "Annals of Neurology"

DOI: 10.1002/ana.25698

Abstract: Traumatic brain injury is a major risk factor for acquired epilepsies, and understanding the mechanisms underlying the early pathophysiology could yield viable therapeutic targets. Growing evidence indicates a role for inflammatory signaling in modifying neuronal… read more here.

Keywords: toll like; epileptogenesis; like receptor; receptor signaling ... See more keywords
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Mice lacking L‐12/15‐lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis

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recommendations! Published in 2018 at "Epilepsia Open"

DOI: 10.1002/epi4.12221

Abstract: Studies have addressed the potential involvement of L‐12/15‐lipoxygenases (LOs), a polyunsaturated fatty acid metabolizing enzyme, in experimental models of acute stroke and chronic neurodegeneration; however, none to our knowledge has explored its role in epilepsy… read more here.

Keywords: increased mortality; epileptogenesis; show increased; mice lacking ... See more keywords

Converging early responses to brain injury pave the road to epileptogenesis

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recommendations! Published in 2017 at "Journal of Neuroscience Research"

DOI: 10.1002/jnr.24202

Abstract: Epilepsy, characterized by recurrent seizures and abnormal electrical activity in the brain, is one of the most prevalent brain disorders. Over two million people in the United States have been diagnosed with epilepsy and 3%… read more here.

Keywords: epilepsy; epileptogenesis; brain; brain injury ... See more keywords
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Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus

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recommendations! Published in 2018 at "Epilepsy Research"

DOI: 10.1016/j.eplepsyres.2018.02.008

Abstract: OBJECTIVE Status epilepticus (SE) causes neuronal cell death, aberrant mossy fiber sprouting (MFS), and cognitive deteriorations. The present study tested the hypothesis that systemically infused mesenchymal stem cells (MSCs) reduce epileptogenesis by inhibiting neuronal cell… read more here.

Keywords: epileptogenesis; infusion; status epilepticus; model ... See more keywords
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Ultrastructural and functional changes at the tripartite synapse during epileptogenesis in a model of temporal lobe epilepsy

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recommendations! Published in 2020 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2020.113196

Abstract: The persistent unresponsiveness of many of the acquired epilepsies to traditional antiseizure medications has motivated the search for prophylactic drug therapies that could reduce the incidence of epilepsy in this at risk population. These studies… read more here.

Keywords: epilepsy; epileptogenesis; period; ultrastructural functional ... See more keywords
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Agomelatine protects against neuronal damage without preventing epileptogenesis in the kainate model of temporal lobe epilepsy

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recommendations! Published in 2017 at "Neurobiology of Disease"

DOI: 10.1016/j.nbd.2017.04.017

Abstract: Recent studies about the novel antidepressant agomelatine, which is a mixed MT1 and MT2 melatonin receptor agonist and 5HT2C serotonin receptor antagonist possessing an anticonvulsant and neuroprotective action, suggest that it may have potential to… read more here.

Keywords: epilepsy; neuronal damage; lobe epilepsy; epileptogenesis ... See more keywords
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Seizure-induced reduction in glucose utilization promotes brain hypometabolism during epileptogenesis

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recommendations! Published in 2018 at "Neurobiology of Disease"

DOI: 10.1016/j.nbd.2018.04.016

Abstract: Brain glucose hypometabolism is an early symptom of acquired epilepsy, its causative mechanism yet unclear. We suggest that a bidirectional positive feedback linking seizures and hypometabolism (hypometabolism induces seizures while seizures disrupt glucose metabolism) may… read more here.

Keywords: epileptogenesis; hypometabolism; seizure induced; glucose metabolism ... See more keywords
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Changes of dimension of EEG/ECoG nonlinear dynamics predict epileptogenesis and therapy outcomes

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recommendations! Published in 2019 at "Neurobiology of Disease"

DOI: 10.1016/j.nbd.2018.12.014

Abstract: The lack of early biomarkers of epileptogenesis precludes a sound prediction of epilepsy development after acute brain injuries and of the natural course of the disease thus impairing the development of antiepileptogenic treatments. We investigated… read more here.

Keywords: ecog nonlinear; epileptogenesis; nonlinear dynamics; dimension eeg ... See more keywords
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Epigenetic principles underlying epileptogenesis and epilepsy syndromes

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recommendations! Published in 2021 at "Neurobiology of Disease"

DOI: 10.1016/j.nbd.2020.105179

Abstract: Epilepsy is a network disorder driven by fundamental changes in the function of the cells which compose these networks. Driving this aberrant cellular function are large scale changes in gene expression and gene expression regulation.… read more here.

Keywords: epilepsy; epileptogenesis; gene expression; epigenetic principles ... See more keywords
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The holy grail of epilepsy prevention: Preclinical approaches to antiepileptogenic treatments

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recommendations! Published in 2020 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2019.04.011

Abstract: A variety of acute brain insults can induce epileptogenesis, a complex process that results in acquired epilepsy. Despite advances in understanding mechanisms of epileptogenesis, there is currently no approved treatment that prevents the development or… read more here.

Keywords: epilepsy; holy grail; epileptogenesis; grail epilepsy ... See more keywords
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Regulation of Alzheimer's disease-associated proteins during the course of epileptogenesis: differential proteomic analysis in a rat model.

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recommendations! Published in 2019 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2019.08.037

Abstract: Clinical evidence and pathological studies suggest a bidirectional link between temporal lobe epilepsy and Alzheimer's disease. Data analysis from omic studies offers an excellent opportunity to identify the overlap in molecular alterations between the two… read more here.

Keywords: epileptogenesis; alzheimer disease; analysis; rat model ... See more keywords