C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides from Campylobacter jejuni.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00364
Abstract: Campylobacter jejuni is a human pathogen and one of the leading causes of food poisoning in Europe and the United States. The outside of the bacterium is coated with a capsular polysaccharide that assists in… read more here.
Keywords: epimerization; campylobacter jejuni; catalyze epimerization; required biosynthesis ... See more keywords
Visible Light-Mediated, Highly Diastereoselective Epimerization of Lactams from the Most Accessible to the More Stable Stereoisomer.
Sign Up to like & getrecommendations! Published in 2022 at "ACS catalysis"
DOI: 10.1021/acscatal.2c02232
Abstract: Most known methods to access δ-lactams with stereogenic centers at the α- and β-positions are highly selective for the contra-thermodynamic syn diastereomer, typically via hydrogenation of the corresponding pyridinones or quinolinones. We describe here the… read more here.
Keywords: epimerization; highly diastereoselective; mediated highly; visible light ... See more keywords
Visible Light-Mediated, Diastereoselective Epimerization of Morpholines and Piperazines to More Stable Isomers.
Sign Up to like & getrecommendations! Published in 2022 at "ACS catalysis"
DOI: 10.1021/acscatal.2c03672
Abstract: We report a photocatalyzed epimerization of morpholines and piperazines that proceeds by reversible hydrogen atom transfer (HAT) and provides an efficient strategy for editing the stereochemical configurations of these saturated nitrogen heterocycles, which are prevalent… read more here.
Keywords: epimerization; epimerization morpholines; morpholines piperazines; visible light ... See more keywords
Theoretical Study on the Epimerization of Azlactone Rings: Keto–Enol Tautomerism or Base-Mediated Racemization?
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b00060
Abstract: Azlactones are versatile heterocycles employed in a diversity of transformations; the main drawback of these cycles consists in the epimerization of the α-carbonyl stereocenter during its preparation. We hereby present a theoretical study to explain… read more here.
Keywords: tautomerism base; theoretical study; racemization; keto enol ... See more keywords
General Light-Mediated, Highly Diastereoselective Piperidine Epimerization: From Most Accessible to Most Stable Stereoisomer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c11911
Abstract: We report a combined photocatalytic and hydrogen atom transfer (HAT) approach for the light-mediated epimerization of readily accessible piperidines to provide the more stable diastereomer with high selectivity. The generality of the transformation was explored… read more here.
Keywords: general light; light mediated; epimerization; mediated highly ... See more keywords
Selective Axial-to-Equatorial Epimerization of Carbohydrates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c04743
Abstract: Radical-mediated transformations have emerged as powerful methods for the synthesis of rare and unnatural branched, deoxygenated, and isomeric sugars. Here, we describe a radical-mediated axial-to-equatorial alcohol epimerization method to transform abundant glycans into rare isomers.… read more here.
Keywords: axial equatorial; epimerization; selective axial; epimerization carbohydrates ... See more keywords
A Concise Synthesis of Pleurotin Enabled by a Nontraditional C-H Epimerization.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c06504
Abstract: An 8-step synthesis of a known pentacyclic intermediate toward the natural product pleurotin (1) is described. Pleurotin and related benzoquinone natural products are of great interest for their powerful anticancer and antibiotic activities. The route… read more here.
Keywords: synthesis pleurotin; epimerization; pleurotin enabled; synthesis ... See more keywords
Highly Diastereoselective Functionalization of Piperidines by Photoredox Catalyzed α-Amino C-H Arylation and Epimerization.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b13165
Abstract: We report a photoredox catalyzed α-amino C-H arylation reaction of highly substituted piperidine derivatives with electron deficient cyano(hetero)arenes. The scope and limitations of the reaction were explored, with piperidines bearing multiple substitution patterns providing the… read more here.
Keywords: amino arylation; catalyzed amino; epimerization; arylation ... See more keywords
The enzymatic epimerization of deoxynivalenol by Devosia mutans proceeds through the formation of 3-keto-DON intermediate
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07319-0
Abstract: The enzymatic detoxification of deoxynivalenol (DON) is a promising mitigation strategy for addressing this mycotoxin contamination of cereal grains. A recently described bacterium, Devosia mutans 17-2-E-8, capable of transforming DON into its non-toxic stereoisomer 3-epi-DON,… read more here.
Keywords: devosia mutans; keto intermediate; deoxynivalenol; epimerization ... See more keywords
The enzymatic detoxification of the mycotoxin deoxynivalenol: identification of DepA from the DON epimerization pathway
Sign Up to like & getrecommendations! Published in 2018 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.12874
Abstract: The biological detoxification of mycotoxins, including deoxynivalenol (DON), represents a very promising approach to address the challenging problem of cereal grain contamination. The recent discovery of Devosia mutans 17‐2‐E‐8 (Devosia spp. 17‐2‐E‐8), a bacterial isolate… read more here.
Keywords: deoxynivalenol; epimerization; identification; enzymatic detoxification ... See more keywords
Engineering of Escherichia coli for D-allose fermentative synthesis from D-glucose through izumoring cascade epimerization
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1050808
Abstract: D-Allose is a potential alternative to sucrose in the food industries and a useful additive for the healthcare products in the future. At present, the methods for large-scale production of D-allose are still under investigation,… read more here.
Keywords: escherichia coli; fermentative synthesis; epimerization; coli ... See more keywords