Morphological fingerprinting: Identifying patients with first‐episode schizophrenia using auto‐encoded morphological patterns
Sign Up to like & getrecommendations! Published in 2022 at "Human Brain Mapping"
DOI: 10.1002/hbm.26098
Abstract: Although a large number of case–control statistical and machine learning studies have been conducted to investigate structural brain changes in schizophrenia, how best to measure and characterize structural abnormalities for use in classification algorithms remains… read more here.
Keywords: encoded morphological; episode schizophrenia; first episode; auto encoded ... See more keywords
Progressive symptom-associated prefrontal volume loss occurs in first-episode schizophrenia but not in affective psychosis
Sign Up to like & getrecommendations! Published in 2018 at "Brain Structure and Function"
DOI: 10.1007/s00429-018-1634-0
Abstract: Although smaller gray matter volumes (GMV) in the prefrontal cortex (PFC) in schizophrenia and bipolar disorder have been reported cross-sectionally, there are, to our knowledge, no reports of longitudinal comparisons using manually drawn, gyrally based… read more here.
Keywords: affective psychosis; first episode; gmv; episode schizophrenia ... See more keywords
Case study of first episode schizophrenia in pregnancy and postpartum
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Women's Mental Health"
DOI: 10.1007/s00737-017-0748-3
Abstract: Patients with first-episode psychosis of peripartum onset commonly prove to have a mood-disorder diathesis; however, a proportion of cases represent first-episode schizophrenia. We present such a case and discuss the clinical relevance of recognizing this… read more here.
Keywords: study first; first episode; episode schizophrenia; therapy ... See more keywords
Inflammatory and Oxidative Pathways Are New Drug Targets in Multiple Episode Schizophrenia and Leaky Gut, Klebsiella pneumoniae, and C1q Immune Complexes Are Additional Drug Targets in First Episode Schizophrenia.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02343-8
Abstract: Breakdown of paracellular and vascular pathways and activated neuroimmune and oxidative pathways was established in (deficit) schizophrenia. The aim of this study was to delineate (a) the differences in these pathways between stable-phase, first (FES)… read more here.
Keywords: drug targets; schizophrenia; pneumoniae; c1q ... See more keywords
07-Connectivity of the anterior insula differentiates participants with first-episode schizophrenia spectrum disorders from controls: A machine-learning study
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2018.01.027
Abstract: Early diagnosis of schizophrenia might reduce the negative impact of the untreated disease. Progressive functional/structural changes were repeatedly detected using classical between-group statistics. However, these findings have been due to their low sensitivity and specificity… read more here.
Keywords: machine; machine learning; first episode; episode schizophrenia ... See more keywords
EEG coherence in a mental arithmetic task performance in first episode schizophrenia and schizoaffective disorder
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2018.08.020
Abstract: OBJECTIVES To evaluate the coherence values of the cortical bands in patients with first episode schizophrenia and schizoaffective disorder during the performance of a mental arithmetic task. METHOD We analysed EEG coherence in the resting… read more here.
Keywords: schizoaffective disorder; coherence; first episode; episode schizophrenia ... See more keywords
Translational research identifies a metabolism pathway involved in first-episode of schizophrenia: Towards precision medicine
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.07.026
Abstract: Schizophrenia is a chronic psychiatric disorderwith a heterogeneous studied the effects of betaine supplementation in inbred B6N and genetic and neurobiological background that impacts early brain development and is expressed as a combination of psychotic… read more here.
Keywords: medicine; schizophrenia; metabolism pathway; first episode ... See more keywords
Insulin-signaling abnormalities in drug-naïve first-episode schizophrenia: Transduction protein analyses in extracellular vesicles of putative neuronal origin
Sign Up to like & getrecommendations! Published in 2019 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2019.08.012
Abstract: Abstract Background: Metabolic syndrome and impaired insulin sensitivity may occur as side effects of atypical antipsychotic drugs. However, studies of peripheral insulin resistance using the homeostatic model assessment of insulin resistance (HOMA-IR) or oral glucose… read more here.
Keywords: extracellular vesicles; insulin; first episode; neuronal origin ... See more keywords
First-episode schizophrenia is associated with a reduction of HERV-K methylation in peripheral blood
Sign Up to like & getrecommendations! Published in 2019 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2018.12.012
Abstract: Human endogenous retroviruses (HERV) have been widely associated with schizophrenia etiology. Aberrant epigenetic processes may play a role in the etiology of schizophrenia. In this study, we tested whether schizophrenia patients at different stages of… read more here.
Keywords: methylation; schizophrenia; etiology; herv methylation ... See more keywords
Omega-3 fatty acid supplementation may prevent loss of gray matter thickness in the left parieto-occipital cortex in first episode schizophrenia: A secondary outcome analysis of the OFFER randomized controlled study
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2017.10.013
Abstract: The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled… read more here.
Keywords: schizophrenia; randomized controlled; first episode; study ... See more keywords
Normal categorical perception to syllable-like stimuli in long term and in first episode schizophrenia
Sign Up to like & getrecommendations! Published in 2019 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2019.03.028
Abstract: Schizophrenia is associated with deficits in language processing that are evident even at first-episode. However, there is debate as to how early in the processing stream the linguistic deficits appear. We measured categorical processing of… read more here.
Keywords: schizophrenia; long term; first episode; categorical perception ... See more keywords