Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination at oriP and viral episome maintenance
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2020.12.022
Abstract: Epstein-Barr virus (EBV) is an oncogenic human herpesvirus that persists as a multicopy episome in proliferating host cells. Episome maintenance is strictly dependent on EBNA1, a sequence-specific DNA-binding protein with no known enzymatic activities. Here,… read more here.
Keywords: replication; replication termination; episome maintenance; dna ... See more keywords
Control of Viral Latency by Episome Maintenance Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in microbiology"
DOI: 10.1016/j.tim.2019.09.002
Abstract: The human DNA tumor viruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), and human papillomavirus (HPV) share the common property of persisting as multicopy episomes in the nuclei of rapidly dividing host cells. These episomes… read more here.
Keywords: episome maintenance; viral latency; maintenance; latency episome ... See more keywords