Epistasis Analysis: Classification Through Machine Learning Methods.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0947-7_21
Abstract: Complex disease is different from Mendelian disorders. Its development usually involves the interaction of multiple genes or the interaction between genes and the environment (i.e. epistasis). Although the high-throughput sequencing technologies for complex diseases have produced… read more here.
Keywords: machine learning; epistasis analysis; epistasis; learning methods ... See more keywords
DCA for genome-wide epistasis analysis: the statistical genetics perspective.
Sign Up to like & getrecommendations! Published in 2019 at "Physical biology"
DOI: 10.1088/1478-3975/aafbe0
Abstract: Direct coupling analysis (DCA) is a now widely used method to leverage statistical information from many similar biological systems to draw meaningful conclusions on each system separately. DCA has been applied with great success to… read more here.
Keywords: dca genome; genome wide; wide epistasis; genetics ... See more keywords
Dynamics in Epistasis Analysis
Sign Up to like & getrecommendations! Published in 2018 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2017.2653110
Abstract: Finding regulatory relationships between genes, including the direction and nature of influence between them, is a fundamental challenge in the field of molecular genetics. One classical approach to this problem is epistasis analysis. Broadly speaking,… read more here.
Keywords: analysis; dynamics epistasis; epistasis analysis; power ... See more keywords
Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1006508
Abstract: Recent advances in the scale and diversity of population genomic datasets for bacteria now provide the potential for genome-wide patterns of co-evolution to be studied at the resolution of individual bases. Here we describe a… read more here.
Keywords: genome wide; analysis; epistasis analysis; resistance ... See more keywords