Epistasis shapes the fitness landscape of an allosteric specificity switch
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DOI: 10.1038/s41467-021-25826-7
Abstract: Epistasis is a major determinant in the emergence of novel protein function. In allosteric proteins, direct interactions between inducer-binding mutations propagate through the allosteric network, manifesting as epistasis at the level of biological function. Elucidating… read more here.
Keywords: fitness landscape; allosteric proteins; epistasis shapes; specificity ... See more keywords