Influence of epistatic effects on various traits in relation to the genetic improvement of opium poppy (Papaver somniferum L.)
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Research on Medicinal and Aromatic Plants"
DOI: 10.1016/j.jarmap.2021.100322
Abstract: Absract The information on gene interactions is a basic requirement for exploitation of genetic variability and advancement in the development of high yielding lines in any crop. The present study was taken to discover the… read more here.
Keywords: various traits; opium; influence epistatic; effects various ... See more keywords
Exhaustive search for epistatic effects on the human methylome
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13256-9
Abstract: Studies assessing the existence and magnitude of epistatic effects on complex human traits provide inconclusive results. The study of such effects is complicated by considerable increase in computational burden, model complexity, and model uncertainty, which… read more here.
Keywords: search epistatic; epistatic effects; exhaustive search; effects human ... See more keywords
Epistatic interaction has the reverse effects with its constitutive quantitative trait loci
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-69236-3
Abstract: Epistasis is one of important genetic components for a quantitative trait in plant. Eshed and Zamir found negative epistatic interactions of quantitative trait loci in Tomato first. We detected that positive (negative) QTLs generated mostly… read more here.
Keywords: interaction reverse; trait loci; epistatic effects; quantitative trait ... See more keywords
Genome-wide unraveling SNP pairwise epistatic effects associated with sheep body weight.
Sign Up to like & getrecommendations! Published in 2022 at "Animal biotechnology"
DOI: 10.1080/10495398.2022.2152349
Abstract: Epistatic effects are an important part of the genetic effect of complex traits in livestock. In this study, we used 218 synthetic ewes from the Xinjiang Academy of Agricultural Reclamation in China to identify interacting… read more here.
Keywords: weaning weight; genome wide; body weight; epistatic effects ... See more keywords
Epistatic Effects Between Amino Acid Insertions and Substitutions Mediate Toxin resistance of Vertebrate Na+,K+-ATPases
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac258
Abstract: The recurrent evolution of resistance to cardiotonic steroids (CTS) across diverse animals most frequently involves convergent amino-acid substitutions to the H1-H2 extracellular loop of Na+,K+-ATPase (NKA). Previous work established that hystricognath rodents (e.g. chinchilla) and… read more here.
Keywords: effects amino; acid insertions; resistance; amino acid ... See more keywords
Abstract 862: Pairwise and higher-order epistatic effects among somatic cancer mutations across oncogenesis of lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-862
Abstract: The somatic evolution of cancer depends on the rate at which new mutations are acquired, as well as the selective pressure acting on them. Further, mutual exclusivity or co-occurrence of mutations suggests that variants can… read more here.
Keywords: pairwise higher; higher order; lung; order epistatic ... See more keywords
Abstract IA014: Detecting epistatic effects among somatic cancer mutations across oncogenesis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.canevol23-ia014
Abstract: The somatic evolution of cancer depends on the rate at which new mutations are acquired, as well as the selective pressure acting on them. Further, mutual exclusivity or co-occurrence of somatic variants suggests that current… read more here.
Keywords: detecting epistatic; cancer; somatic cancer; mutation ... See more keywords
Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1095830
Abstract: Systemic lupus erythematosus (SLE) is a severe autoimmune disease that displays considerable heterogeneity not only in its symptoms, but also in its environmental and genetic causes. Studies in SLE patients have revealed that many genetic… read more here.
Keywords: sle; dnase1 dnase1l3; development; etiology ... See more keywords