Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome‐Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1359
Abstract: Anastrozole is a widely prescribed aromatase inhibitor for the therapy of estrogen receptor positive (ER+) breast cancer. We performed a genome‐wide association study (GWAS) for plasma anastrozole concentrations in 687 postmenopausal women with ER+ breast… read more here.
Keywords: genome wide; slc38a7; aromatase inhibitor; epistatic interaction ... See more keywords
Epistatic interaction has the reverse effects with its constitutive quantitative trait loci
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DOI: 10.1038/s41598-024-69236-3
Abstract: Epistasis is one of important genetic components for a quantitative trait in plant. Eshed and Zamir found negative epistatic interactions of quantitative trait loci in Tomato first. We detected that positive (negative) QTLs generated mostly… read more here.
Keywords: interaction reverse; trait loci; epistatic effects; quantitative trait ... See more keywords
Tracing the Origin of the RSPO2 Long-Hair Allele and Epistatic Interaction between FGF5 and RSPO2 in Sapsaree Dog
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DOI: 10.3390/genes13010102
Abstract: Genetic analysis of the hair-length of Sapsaree dogs, a Korean native dog breed, showed a dominant mode of inheritance for long hair. Genome-Wide Association Study (GWAS) analysis and subsequent Mendelian segregation analysis revealed an association… read more here.
Keywords: rspo2; epistatic interaction; insertion; long hair ... See more keywords