Stronger together
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Microbiology"
DOI: 10.1038/nrmicro.2017.95
Abstract: Susceptibility to infectious diseases and disease severity may be affected by interactions between the genomes of the host and pathogen. Although the effect of variations in gene sequence on disease has been studied for several… read more here.
Keywords: analysis; stronger together; genome; host pathogen ... See more keywords
Identification of genomic regions for grain yield and yield stability and their epistatic interactions
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41578
Abstract: The task of identifying genomic regions conferring yield stability is challenging in any crop and requires large experimental data sets in conjunction with complex analytical approaches. We report findings of a first attempt to identify… read more here.
Keywords: yield stability; grain yield; genomic regions; yield ... See more keywords
Epi-MEIF: detecting higher order epistatic interactions for complex traits using mixed effect conditional inference forests
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac715
Abstract: Abstract Understanding the relationship between genetic variations and variations in complex and quantitative phenotypes remains an ongoing challenge. While Genome-wide association studies (GWAS) have become a vital tool for identifying single-locus associations, we lack methods… read more here.
Keywords: using mixed; mixed effect; higher order; effect conditional ... See more keywords
SHEIB-AGM: A Novel Stochastic Approach for Detecting High-Order Epistatic Interactions Using Bioinformation With Automatic Gene Matrix in Genome-Wide Association Studies
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Access"
DOI: 10.1109/access.2020.2969465
Abstract: Detecting epistatic interactions in GWAS (genome-wide association studies) data is of great significance in studying common and complex diseases; however, the ability to detect high-order epistatic interactions in GWAS data is still insufficient. Existing methods… read more here.
Keywords: order; gene; sheib agm; epistatic interactions ... See more keywords
Epistatic drift causes gradual decay of predictability in protein evolution
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abn6895
Abstract: Epistatic interactions can make the outcomes of evolution unpredictable, but no comprehensive data are available on the extent and temporal dynamics of changes in the effects of mutations as protein sequences evolve. Here, we use… read more here.
Keywords: drift causes; evolution epistatic; epistatic interactions; epistatic drift ... See more keywords
GEP-EpiSeeker: a gene expression programming-based method for epistatic interaction detection in genome-wide association studies
Sign Up to like & getrecommendations! Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-08207-8
Abstract: Background Identification of epistatic interactions provides a systematic way for exploring associations among different single nucleotide polymorphism (SNP) and complex diseases. Although considerable progress has been made in epistasis detection, efficiently and accurately identifying epistatic… read more here.
Keywords: expression programming; gep episeeker; detection; epistatic interactions ... See more keywords
Evaluating the detection ability of a range of epistasis detection methods on simulated data for pure and impure epistatic models
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263390
Abstract: Background Numerous approaches have been proposed for the detection of epistatic interactions within GWAS datasets in order to better understand the drivers of disease and genetics. Methods A selection of state-of-the-art approaches were assessed. These… read more here.
Keywords: epistasis detection; impure epistatic; impure; detection ... See more keywords
Intergenomic and epistatic interactions control free radical mediated pancreatic β-cell damage
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.994501
Abstract: Alloxan (AL)-generated Reactive Oxygen Species (ROS) selectively destroy insulin-producing pancreatic β-cells. A previous genome-wide scan (GWS) using a cohort of 296 F2 hybrids between NOD (AL-sensitive) and ALR (AL-resistant) mice identified linkages contributing to β-cell… read more here.
Keywords: linkages chr; cell; control free; epistatic interactions ... See more keywords
MDSN: A Module Detection Method for Identifying High-Order Epistatic Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13122403
Abstract: Epistatic interactions are referred to as SNPs (single nucleotide polymorphisms) that affect disease development and trait expression nonlinearly, and hence identifying epistatic interactions plays a great role in explaining the pathogenesis and genetic heterogeneity of… read more here.
Keywords: epistatic interactions; high order; module detection; order ... See more keywords