&Dgr;9‐tetrahydrocannabivarin impairs epithelial calcium transport through inhibition of TRPV5 and TRPV6
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.08.021
Abstract: ABSTRACT Compounds extracted from the cannabis plant, including the psychoactive &Dgr;9‐tetrahydrocannabinol (THC) and related phytocannabinoids, evoke multiple diverse biological actions as ligands of the G protein‐coupled cannabinoid receptors CB1 and CB2. In addition, there is… read more here.
Keywords: epithelial calcium; trpv5 trpv6; dgr;
Inactivation-mimicking block of the epithelial calcium channel TRPV6
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abe1508
Abstract: Small-molecule piperazine derivatives mimic inactivation by calmodulin to selectively and potently block TRPV6 channels. Epithelial calcium channel TRPV6 plays vital roles in calcium homeostasis, and its dysregulation is implicated in multifactorial diseases, including cancers. Here,… read more here.
Keywords: calcium channel; channel; epithelial calcium; inactivation ... See more keywords