New insights regarding epithelial Na+ channel regulation and its role in the kidney, immune system and vasculature
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000479
Abstract: Purpose of review This review describes recent findings regarding the epithelial Na+ channel (ENaC) and its roles in physiologic and pathophysiologic states. We discuss new insights regarding ENaC's structure, its regulation by various factors, its… read more here.
Keywords: role; immune system; regarding epithelial; system vasculature ... See more keywords
Rare Variants in Genes Encoding Subunits of the Epithelial Na+ Channel Are Associated With Blood Pressure and Kidney Function
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DOI: 10.1161/hypertensionaha.121.18513
Abstract: Background: The epithelial Na+ channel (ENaC) is intrinsically linked to fluid volume homeostasis and blood pressure. Specific rare mutations in SCNN1A, SCNN1B, and SCNN1G, genes encoding the α, β, and γ subunits of ENaC, respectively,… read more here.
Keywords: genes encoding; kidney; pressure; epithelial channel ... See more keywords
Validation of commercially available antibodies directed against subunits of the epithelial Na+ channel
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DOI: 10.14814/phy2.15554
Abstract: The epithelial Na+ channel (ENaC) is traditionally composed of three subunits, although non‐canonical expression has been found in various tissues including the vasculature, brain, lung, and dendritic cells of the immune system. Studies of ENaC… read more here.
Keywords: available antibodies; antibodies directed; validation commercially; epithelial channel ... See more keywords