EphA7 is required for otic epithelial homeostasis by modulating Claudin6 in Xenopus.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.099
Abstract: Receptor tyrosine kinase EphA7 is specifically expressed in otic region in Xenopus early development. However, its role in otocyst development remains unknown. Knockdown of EphA7 by a specific morpholino oligonucleotide (MO) reduced the size of… read more here.
Keywords: epha7 required; required otic; otic epithelial; homeostasis modulating ... See more keywords
Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2016.12.004
Abstract: ABSTRACT The importance of cyclooxygenase and lipoxygenase pathways and the consequent eicosanoid synthesis in the physiology and pathophysiology of the intestinal epithelium is currently being established. Each eicosanoid (prostanoid, leukotriene, hydroxyeicosatetraenoic acid) preferentially recognizes one… read more here.
Keywords: receptors targets; intestinal epithelium; eicosanoid receptors; physiology ... See more keywords
Mechanisms and regulation of IL-22-mediated intestinal epithelial homeostasis and repair.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119195
Abstract: AIMS Ulcerative colitis and Crohn's disease, collectively known as inflammatory bowel disease (IBD), are chronic inflammatory disorders of the intestine for which key elements in disease initiation and perpetuation are defects in epithelial barrier integrity.… read more here.
Keywords: homeostasis repair; cell; intestinal epithelial; epithelial homeostasis ... See more keywords
The H2A.Z histone variant integrates Wnt signaling in intestinal epithelial homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09899-z
Abstract: The Tip60/p400 chromatin-modifying complex, which is involved in the incorporation and post-translational modification of the H2A.Z histone variant, regulates cell proliferation and important signaling pathways, such as Wnt. Here, we study the involvement of H2A.Z… read more here.
Keywords: homeostasis; intestinal epithelial; histone variant; h2a ... See more keywords
Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.156612
Abstract: Intestinal epithelial integrity is commonly disrupted in patients with critical disorders, but the exact underlying mechanisms are unclear. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions and are involved in pathologies.… read more here.
Keywords: binding protein; cug binding; long noncoding; epithelial homeostasis ... See more keywords
Scribble and α-Catenin cooperatively regulate epithelial homeostasis and growth
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.912001
Abstract: Epithelial homeostasis is an emergent property of both physical and biochemical signals emanating from neighboring cells and across tissue. A recent study reveals that Scribble, an apico-basal polarity determinant, cooperates with α-Catenin, an adherens junction… read more here.
Keywords: regulate epithelial; homeostasis growth; epithelial homeostasis; catenin ... See more keywords
Role of Muscarinic Acetylcholine Receptors in Intestinal Epithelial Homeostasis: Insights for the Treatment of Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076508
Abstract: Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is an intestinal disorder that causes prolonged inflammation of the gastrointestinal tract. Currently, the etiology of IBD is not fully understood and treatments are… read more here.
Keywords: disease; inflammatory bowel; acetylcholine; epithelial homeostasis ... See more keywords