A collagen hydrogel-based intestinal model enabling physiological epithelial-immune cell interactions in host-microbe studies.
Sign Up to like & getrecommendations! Published in 2025 at "Biomaterials science"
DOI: 10.1039/d5bm00612k
Abstract: The human intestine orchestrates complex immune responses to external stimuli, including trillions of gut microbes. Understanding host-microbiota interactions remains challenging due to the complex cellular composition of intestinal tissues. In this study, we present InTRIC… read more here.
Keywords: intestinal model; epithelial immune; model; immune ... See more keywords
A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology.
Sign Up to like & getrecommendations! Published in 2025 at "Science translational medicine"
DOI: 10.1126/scitranslmed.adu6032
Abstract: Acute graft-versus-host disease (aGVHD) is a severe complication of allogeneic hematopoietic stem cell transplantation, driven by alloreactive donor T cells in the gut. However, the roles of additional donor and host cells in this process… read more here.
Keywords: disease; immune dynamics; spatial atlas; across individuals ... See more keywords
Abstract PR018: Spatially resolved epithelial and immune heterogeneity reveals distinct endometriosis-related precursors to ovarian cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.ovarian25-pr018
Abstract: Evidence suggests that certain histotypes of ovarian carcinoma -mainly clear cell (CCOC) and endometrioid (EOC) carcinoma-may arise from endometriosis (EAOC), although the biological mechanisms underlying this phenomenon remain unclear. Previously, we identified that approximately one-third… read more here.
Keywords: cancer; endometriosis related; epithelial immune; ovarian cancer ... See more keywords
Single-Cell RNA-seq Reveals Aberrant Airway Epithelial-Immune Cell Crosstalk In Pulmonary Fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "ERJ Open Research"
DOI: 10.1183/23120541.01273-2025
Abstract: Epithelial-immune cell interactions are crucial in the regulation of pulmonary immune responses. Emerging evidence suggests that cell populations lining the airways may play a pivotal role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a… read more here.
Keywords: disease; ipf; epithelial immune; cell ... See more keywords
Interactions between microbiota and cervical epithelial, immune, and mucus barrier
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1124591
Abstract: The female reproductive tract harbours hundreds of bacterial species and produces numerous metabolites. The uterine cervix is located between the upper and lower parts of the female genital tract. It allows sperm and birth passage… read more here.
Keywords: barrier; mucus barrier; immune mucus; cervical epithelial ... See more keywords
Epithelial and immune transcriptomic characteristics and possible regulatory mechanisms in asthma exacerbation: insights from integrated studies
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1512053
Abstract: Background Asthma exacerbation significantly contribute to disease mortality and result in heightened health care expenditures. This study was aimed at gaining important new insights into the heterogeneity of epithelial and immune cells and elucidating key… read more here.
Keywords: regulatory genes; key regulatory; epithelial immune; cell ... See more keywords